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Caught the''Catch''of midnolin:structural basis for broad substrate specificity in ubiquitin-independent proteasomal degradation

Chuanyin Li Ronggui Hu

Acta Biochimica et Biophysica Sinica2026，Vol.58Issue(6)：P.1431-1432,2.

Acta Biochimica et Biophysica Sinica2026，Vol.58Issue(6)：P.1431-1432,2.DOI:10.3724/abbs.2026006

Caught the''Catch''of midnolin:structural basis for broad substrate specificity in ubiquitin-independent proteasomal degradation

Chuanyin Li ¹Ronggui Hu²

作者信息

1. Department of Colorectal Surgery and Oncology(Key Laboratory of Cancer Prevention and Intervention,China National Ministry of Education,Key Laboratory of Molecular Biology in Medical Sciences,Zhejiang Province,China),the Second Affiliated Hospital,Zhejiang University School of Medicine,Hangzhou 310009,China Center for Medical Research and Innovation in Digestive System Tumors,Ministry of Education,Hangzhou 310009,China
2. Department of Colorectal Surgery and Oncology(Key Laboratory of Cancer Prevention and Intervention,China National Ministry of Education,Key Laboratory of Molecular Biology in Medical Sciences,Zhejiang Province,China),the Second Affiliated Hospital,Zhejiang University School of Medicine,Hangzhou 310009,China Center for Medical Research and Innovation in Digestive System Tumors,Ministry of Education,Hangzhou 310009,China Liangzhu Laboratory,M0E Frontier Science Center for Brain Science and Brain-Machine Integration,State Key Laboratory of Brain-Machine Intelligence,Zhejiang University,Hangzhou 310009,China
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摘要

关键词

e conjugating enzymes/covalent attachment polyubiquitin chainsa/protein homeostasis/neurological disorders/proteasomal degradation/substrate specificity/ubiquitin independent degradation/e activating enzymes

分类

生物科学

引用本文复制引用

Chuanyin Li,Ronggui Hu..Caught the''Catch''of midnolin:structural basis for broad substrate specificity in ubiquitin-independent proteasomal degradation[J].Acta Biochimica et Biophysica Sinica,2026,58(6):P.1431-1432,2.

基金项目

supported by the grants from the National Natural Science Foundation of China(Nos.92253302,82200667 and 31900804) （Nos.92253302,82200667 and 31900804）

the National Science and Technology Innovation 2030 Major Project of China(No.2021ZD0203900)。（No.2021ZD0203900）

Acta Biochimica et Biophysica Sinica

ISSN：1672-9145

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