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Tubulin hyperglutamylation induces retinal degeneration by disrupting ciliary architecture and protein trafficking

Hao-Lin Wang Ting Wang Fang-Yuan Zhen Yong-Qiong Lin Ying-Jie Tong Jia-Hui Wu Jia-Xin Guo Jia-Jia Wang Shu-Qian Dong Carsten Janke Maria M.Magiera Hou-Bin Zhang Tong-Dan Zou

Zoological Research2026，Vol.47Issue(2)：P.593-605,13.

Zoological Research2026，Vol.47Issue(2)：P.593-605,13.DOI:10.24272/j.issn.2095-8137.2025.321

Tubulin hyperglutamylation induces retinal degeneration by disrupting ciliary architecture and protein trafficking

Hao-Lin Wang ¹Ting Wang ¹Fang-Yuan Zhen ²Yong-Qiong Lin ¹Ying-Jie Tong ¹Jia-Hui Wu ³Jia-Xin Guo ¹Jia-Jia Wang ¹Shu-Qian Dong ³Carsten Janke ⁴Maria M.Magiera ⁴Hou-Bin Zhang ⁵Tong-Dan Zou¹

作者信息

1. Genetic Diseases Key Laboratory of Sichuan Province and Department of Laboratory Medicine,School of Medicine,Sichuan Provincial People’s Hospital,University of Electronic Science and Technology of China,Chengdu,Sichuan 610072,China
2. State Key Laboratory of Ophthalmology,Zhongshan Ophthalmic Center,Sun Yat-sen University,Guangzhou,Guangdong 510060,China
3. Department of Ophthalmology,First Affiliated Hospital of Zhengzhou University,Henan Provincial Ophthalmic Hospital,Zhengzhou,Henan 450052,China
4. Institut Curie,PSL Research University,Orsay,CNRS UMR3348,France UniversitéParis-Saclay,Orsay,CNRS UMR3348,France
5. Genetic Diseases Key Laboratory of Sichuan Province and Department of Laboratory Medicine,School of Medicine,Sichuan Provincial People’s Hospital,University of Electronic Science and Technology of China,Chengdu,Sichuan 610072,China Research Unit for Blindness Prevention of Chinese Academy of Medical Sciences(2019RU026),Sichuan Academy of Medical Sciences&Sichuan Provincial People’s Hospital,Chengdu,Sichuan 610072,China
折叠

摘要

关键词

AGBL5/Tubulin glutamylation/Connecting cilium/Intraflagellar transport/Photoreceptor/Retinal degeneration

分类

医药卫生

引用本文复制引用

Hao-Lin Wang,Ting Wang,Fang-Yuan Zhen,Yong-Qiong Lin,Ying-Jie Tong,Jia-Hui Wu,Jia-Xin Guo,Jia-Jia Wang,Shu-Qian Dong,Carsten Janke,Maria M.Magiera,Hou-Bin Zhang,Tong-Dan Zou..Tubulin hyperglutamylation induces retinal degeneration by disrupting ciliary architecture and protein trafficking[J].Zoological Research,2026,47(2):P.593-605,13.

基金项目

supported by the National Natural Science Foundation of China(82371059(H.B.Z.),82102470(J.J.W.)) （82371059(H.B.Z.）

Sichuan Science and Technology Program,China(2025ZNSFSC1713(T.D.Z.)) （2025ZNSFSC1713(T.D.Z.）

Sichuan Academy of Medical Sciences and Sichuan Provincial People’s Hospital(2023BH01(T.D.Z.))。（2023BH01(T.D.Z.）

Zoological Research

ISSN：2095-8137

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