长春中医药大学学报2026，Vol.42Issue(8)：906-910,5.DOI:10.13463/j.cnki.cczyy.2026.08.006
基于"菌群-代谢-免疫"轴从"浊毒"论治腹泻型肠易激综合征
Treatment of diarrhea-predominant irritable bowel syndrome from the perspective of turbid toxins based on the microbiota-metabolism-immunity axis
摘要
Abstract
The pathogenesis of diarrhea-predominant irritable bowel syndrome(IBS-D)has not yet been fully elucidated.Its development and progression are closely related to intestinal flora imbalance,metabolic dysregulation,and immune dysfunction,resulting from the interactive interplay of microbiota,metabolism,and immunity.Traditional Chinese Medicine(TCM)posits that the key pathogenesis of IBS-D lies in liver-spleen disharmony.Li Diangui proposes the"Turbid Toxin Theory,"suggesting that liver stagnation-spleen deficiency and internal accumulation of turbid toxins constitute the primary pathogenesis of IBS-D.Based on the"gut microbiota-metabolism-immunity"axis and starting from the turbid-toxin theory,this study explores the correlation between the two.Gut microbiota dysbiosis shares physiological similarities with spleen deficiency.The metabolic disorders and activated immune-inflammatory responses caused by gut microbiota dysbiosis align with the pathogenic characteristics of turbid toxin.Regulating the"gut microbiota-metabolism-immunity"axis by soothing the liver,strengthening the spleen,resolving turbidity,and detoxifying has certain value in treating IBS-D.关键词
肠道菌群/代谢/免疫/浊毒/腹泻型肠易激综合征Key words
gut microbiota/metabolism/immunity/turbid toxins/diarrhea-predominant irritable bowel syndrome分类
医药卫生引用本文复制引用
任志源,袁宇航,高山雪,彭龙,陈婕..基于"菌群-代谢-免疫"轴从"浊毒"论治腹泻型肠易激综合征[J].长春中医药大学学报,2026,42(8):906-910,5.基金项目
天津市教委科研计划项目(自然科学)(2024ZD012) （自然科学）
