中国耳鼻咽喉头颈外科2026，Vol.33Issue(6)：333-337,348,6.DOI:10.16066/j.1672-7002.2026.06.007
人工智能辅助鼻细胞学全定量检测在慢性鼻炎中的临床效度分析
Clinical validity of AI-assisted fully quantitative nasal cytology in chronic rhinitis
摘要
Abstract
OBJECTIVE To systematically evaluate the clinical validity of AI-assisted fully quantitative nasal cytology(hereinafter referred to as quantitative)in chronic rhinitis,including its consistency with traditional semi-quantitative methods,the strength of association with clinical symptoms and serological indicators,and its explanatory power for nasal symptoms.METHODS Nasal smears were collected to obtain traditional semi-quantitative grades(0-4+)and fully quantitative cytological parameters(Eos%,absolute Eos count,degranulated Eos ratio).Serum total IgE,aeroallergen-specific IgE screening,total nasal symptom score(TNSS,0-12),total ocular symptom score(TOSS,0-6),and individual visual analog scale(VAS)scores were simultaneously recorded.Spearman correlation was used to assess correlations,Mann-Whitney U test to compare clinical phenotypic differences,ordinal logistic regression to compare symptom explanatory power,and restricted cubic splines(RCS)to delineate dose-response relationships.RESULTS The fully quantitative Eos count was highly correlated with the semi-quantitative method(Spearman ρ=0.791,P<0.001),while Eos%showed a moderate correlation(ρ=0.575).Fully quantitative Eos%had the strongest correlation with TNSS(ρ=0.254),whereas blood Eos%correlated most strongly with total IgE and aeroallergen-specific IgE screening(ρ=0.19-0.22).In asthma stratification,only blood Eos%showed a significant inter-group difference(P<0.05).Ordinal logistic regression showed that the fully quantitative Eos%model(AIC=1578.2,Nagelkerke R²=0.039)outperformed the semi-quantitative model(AIC=1587.0,R²=0.033)and the blood Eos%model(AIC=1603.1,R²=0.023).RCS revealed a linear dose-response relationship between Eos%and TNSS.CONCLUSION The fully quantitative Eos count is highly consistent with the semi-quantitative method.AI-assisted fully quantitative testing can replace the semi-quantitative approach by providing continuous values and a wider dynamic range.Fully quantitative nasal cytology outperforms traditional semi-quantitative methods in symptom explanatory power,and a stable linear relationship exists between Eos%and TNSS,which can continuously reflect the severity of nasal symptoms.关键词
人工智能/细胞学技术/嗜酸细胞/鼻炎/鼻细胞学/全定量检测/临床效度Key words
Artificial Intelligence/Cytological Techniques/Eosinophils/Rhinitis/nasal cytology/fully quantitative detection/clinical validity引用本文复制引用
宋晓红,宋昱,高云博,张旭,张媛,佘文煜..人工智能辅助鼻细胞学全定量检测在慢性鼻炎中的临床效度分析[J].中国耳鼻咽喉头颈外科,2026,33(6):333-337,348,6.基金项目
国家重点研发计划项目(2022YFC2504100) （2022YFC2504100）
