中国耳鼻咽喉头颈外科2026，Vol.33Issue(6)：338-342,5.DOI:10.16066/j.1672-7002.2026.06.008
季节性过敏性鼻炎患者花粉暴露状态下鼻分泌物嗜酸性粒细胞定量特征及临床意义
Quantitative characteristics and clinical significance of nasal secretion eosinophils in seasonal allergic rhinitis under pollen exposure conditions
摘要
Abstract
OBJECTIVE To compare eosinophilic inflammation in nasal secretions between patients with seasonal allergic rhinitis(SAR)examined during and outside the pollen season,and to assess the associations between eosinophil-related parameters and symptom severity.METHODS A total of 162 patients with SAR who attended Beijing Tongren Hospital between December 2023 and January 2025 were enrolled and divided into pollen-season and non-pollen-season groups according to whether their visit occurred during the pollen season.Nasal secretion smears were evaluated using quantitative cell counting and semiquantitative grading.Associations between eosinophil(Eos)-related parameters and symptom scores were analyzed.RESULTS The pollen-season group included 97 patients,and the non-pollen-season group included 65 patients.Nasal symptom scores,medication scores,peripheral blood Eos percentage and count,as well as nasal secretion Eos percentage,Eos count,proportion of degranulated Eos,and degranulated Eos count were all significantly higher in the pollen-season group.No significant difference was observed in semiquantitative Eos grading between the two groups.Nasal secretion Eos percentage and the proportion of degranulated Eos were positively correlated with multiple nasal symptom scores.CONCLUSION Systemic and local eosinophilic inflammation was increased in patients with SAR during the pollen season.Quantitative assessment of nasal Eos,particularly evaluation of Eos degranulation,may provide an objective reference for assessing inflammation severity and disease activity.关键词
鼻炎,变应性,季节性/细胞学技术/嗜酸细胞/体征和症状Key words
Rhinitis,Allergic,Seasonal/Cytological Techniques/Eosinophils/Signs and Symptoms引用本文复制引用
佘文煜,宋昱,高云博,张旭,张媛,赵妍..季节性过敏性鼻炎患者花粉暴露状态下鼻分泌物嗜酸性粒细胞定量特征及临床意义[J].中国耳鼻咽喉头颈外科,2026,33(6):338-342,5.基金项目
国家重点研发计划项目(2022YFC2504100) （2022YFC2504100）
