广州中医药大学学报2026，Vol.43Issue(8)：2177-2183,7.DOI:10.13359/j.cnki.gzxbtcm.2026.08.021
柴胡桂枝汤联合针刺治疗肝郁脾虚型慢性疲劳综合症的疗效观察
Clinical Observation on the Efficacy of Chaihu Guizhi Decoction Combined with Acupuncture in Treating Chronic Fatigue Syndrome of Liver Depression and Spleen Deficiency Syndrome
摘要
Abstract
Objective To observe the clinical efficacy of Chaihu Guizhi Decoction combined with acupuncture in the treatment of chronic fatigue syndrome(CFS)of liver depression and spleen deficiency syndrome pattern.Methods A total of 99 patients with a confirmed diagnosis of CFS of liver depression and spleen deficiency syndrome pattern,admitted to Wuxi No.2 Chinese Medicine Hospital from February 2025 to May 2025,were enrolled.Using a random number method and sealed envelope method,patients were assigned to a control group(50 cases)and an observation group(49 cases)based on the order of consultation and the odd/even numbers inside the envelopes.The control group received Chaihu Guizhi Decoction,while the observation group received acupuncture in addition to the treatment given to the control group.Both groups were treated continuously for one month.After one month of treatment,the clinical efficacy was evaluated.Changes in traditional Chinese medicine(TCM)syndrome scores,Fatigue Scale-14(FS-14),Fatigue Assessment Instrument(FAI),and Clinical Frailty Scale(CFS)scores,as well as Hamilton Depression Rating Scale(HAMD)and Hamilton Anxiety Rating Scale(HAMA)scores,were observed before and after treatment.Changes in the 36-item Short-Form Health Survey(SF-36)scores were also compared between the two groups.The safety and incidence of adverse reactions were assessed in both groups.Results(1)The total effective rate was 95.92%(47/49)in the observation group and 82.00%(41/50)in the control group.The efficacy of the observation group was superior to that of the control group,and the difference was statistically significant(P＜0.05).(2)After treatment,the TCM syndrome scores in both groups were significantly improved(P＜0.05),and the improvement in the observation group was significantly superior to the control group,the difference being statistically significant(P＜0.05).(3)After treatment,the FS-14,FAI,and CFS scores were significantly improved in both groups(P＜0.05),with the observation group showing significantly greater improvement than the control group,the difference being statistically significant(P＜0.05).(4)After treatment,the HAMD and HAMA scores were significantly improved in both groups(P＜0.05),and the observation group showed significantly better improvement than the control group,the difference being statistically significant(P＜0.05).(5)After treatment,the SF-36 scores was significantly improved in both groups(P＜0.05),and the improvement in the observation group was significantly superior to the control group,the difference being statistically significant(P＜0.05).(6)The incidence of adverse reactions was 4.08%(2/49)in the observation group and 6.00%(3/50)in the control group,with no statistically significant difference between the two groups(P＞0.05).Conclusion Chaihu Guizhi Decoction combined with acupuncture can significantly improve fatigue symptoms,alleviate anxiety and depression,and enhance the quality of life in patients with CFS of liver depression and spleen deficiency syndrome pattern.This combined therapy demonstrates significant efficacy and good safety.关键词
柴胡桂枝汤/针刺/肝郁脾虚/慢性疲劳综合症/焦虑/抑郁/生活质量/临床观察Key words
Chaihu Guizhi Decoction/acupuncture/liver depression and spleen deficiency/chronic fatigue syndrome(CFS)/anxiety/depression/quality of life/clinical observation分类
医药卫生引用本文复制引用
钱蓉蓉,朱云飞,徐容富..柴胡桂枝汤联合针刺治疗肝郁脾虚型慢性疲劳综合症的疗效观察[J].广州中医药大学学报,2026,43(8):2177-2183,7.基金项目
江苏省卫生健康委科研资助项目(编号:H2023216) （编号:H2023216）
