海南医科大学学报2026，Vol.32Issue(15)：1129-1137,9.DOI:10.13210/j.cnki.jhmu.20250327.005
血小板指数与皮肤恶性黑色素瘤的相关性研究
The correlation research between platelet index and cutaneous malignant melanoma
摘要
Abstract
Objective:To investigate the association between genetically determined platelet index and cutaneous malignant melanoma(CMM).Methods:Genetic data of platelet count(PLT),mean platelet volume(MPV),platelet distribution width(PDW),and thrombocytopenia(PCT)from the UK Biobank Database and genetic data of CMM from the FinnGen Database were extracted from Genome-wide association studies(GWAS).Inverse variance weighting(IVW),MR-Egger regression,weighted median and weighted pattern methods were used for Mendelian randomization analysis,and sensitivity analysis was per-formed as well.The effect of platelets on the phenotype of A375 cells was studied in vitro.Results:The IVW analysis of PLT for CMM was OR=1.814,95%CI(1.027,3.203),P=0.040;The IVW analysis of MPV for CMM was OR=0.617,95%CI(0.403,0.945),P=0.026;The IVW analysis of PDW was OR=1.148,95%CI(0.674,1.958),P=0.611;The IVW analysis of PCT was OR=1.238,95%CI(0.727,2.110),P=0.432.In vitro experiments confirmed that platelets could promote the pro-liferation of A375.Conclusion:The increase of platelet count and the decrease of mean platelet volume may be the risk factors for CMM.Increased platelets promote A375 cells proliferation in vitro.关键词
血小板指数/皮肤恶性黑色素瘤/孟德尔随机化Key words
Platelet index/Cutaneous malignant melanoma/Mendelian randomization分类
医药卫生引用本文复制引用
郑瑛瑛,袁梦琪,刘梓燊,吴桐桐,张甘霖,杨国旺..血小板指数与皮肤恶性黑色素瘤的相关性研究[J].海南医科大学学报,2026,32(15):1129-1137,9.基金项目
This study was supported by the National Natural Science Foundation of China(82174453,82374538) （82174453,82374538）
Beijing Natural Science Foundation(7222270) （7222270）
National Science and Technology Major Project(2024ZD0521400) 国家自然科学基金(82174453,82374538) （2024ZD0521400）
北京市自然科学基金(7222270) （7222270）
国家科技重大专项(2024ZD0521400) （2024ZD0521400）
