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Microplastics accumulate in human bile and drive cholangiocyte senescence

Leilei Zhan Li Fu Qingli Zeng Ruiyin Liang Jinhui Tang Juan Liu Bo Qian Zhe Xu Lin Che

环境科学与生态技术（英文）2026，Vol.31Issue(3)：20-35,16.

环境科学与生态技术（英文）2026，Vol.31Issue(3)：20-35,16.DOI:10.1016/j.ese.2026.100686

Microplastics accumulate in human bile and drive cholangiocyte senescence

Leilei Zhan ¹Li Fu ²Qingli Zeng ³Ruiyin Liang ⁴Jinhui Tang ⁵Juan Liu ¹Bo Qian ⁶Zhe Xu ¹Lin Che⁷

作者信息

1. The Tenth Affiliated Hospital of Southern Medical University(Dongguan People's Hospital),Dongguan,523059,China
2. Tianhe District Center for Disease Control and Prevention,Guangzhou,510655,China
3. Department of Emergency Medicine,The First Affiliated Hospital,Sun Yat-sen University,Guangzhou,510080,China
4. The Philippine Women's University,Manila,0900,Philippines
5. Department of Pathophysiology,Guangdong Provincial Key Laboratory of Proteomics,and State Key Laboratory of Organ Failure Research,Southern Medical University,Guangzhou,510515,China
6. Guangxi Key Laboratory of Environmental Exposomics and Entire Lifecycle Health,School of Public Health,Guilin Medical University,Guilin,541199,China
7. State Key Laboratory of Oncology in South China,Sun Yat-sen University Cancer Center,Guangzhou,510060,China||Guangzhou National Laboratory,Guangzhou,510005,China
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摘要

关键词

Microplastics/Multimodal detection/Mitochondrial dysfunction-associated senescence/Human bile/Health risks

Key words

Microplastics/Multimodal detection/Mitochondrial dysfunction-associated senescence/Human bile/Health risks

引用本文复制引用

Leilei Zhan,Li Fu,Qingli Zeng,Ruiyin Liang,Jinhui Tang,Juan Liu,Bo Qian,Zhe Xu,Lin Che..Microplastics accumulate in human bile and drive cholangiocyte senescence[J].环境科学与生态技术（英文）,2026,31(3):20-35,16.

基金项目

This work was supported by the National Natural Science Foundation of China(Grant number 82304180,82460652),Natural Science Foundation of Guangdong Provincial(Grant number 2024A1515010893),Project funded by China Postdoctoral Science Foundation(Grant number 2024T171083,2024MD763959),Post-doctoral Fellowship Program of CPSF(Grant number GZB20250189),and the Social Science and Technology Develop-ment Key Project of Dongguan(Grant number 20211800905292). （Grant number 82304180,82460652）

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