海洋科学2026，Vol.50Issue(2)：37-50,14.DOI:10.11759/hykx20251218002
两个海区福建牡蛎糖原相对高低群体代谢组差异分析
Metabolomic differences of Crassostrea angulata populations from two seas in Fujian based on relatively high and low gly-cogen contents
摘要
Abstract
Oysters are the most productive mariculture shellfish in China,with the national aquaculture output reaching 7,252,500 tons in 2024.Among them,Crassostrea angulata is the main species cultured in Fujian Prov-ince.Glycogen content is a crucial,quality-associated trait that considerably affects oyster flavor.However,re-search on the mechanisms regulating glycogen content in C.angulata is limited,hindering progress in genetic im-provement.In this study,C.angulata from a single population were cultured in two sea areas,Meizhou(Putian)and Shijing(Quanzhou).Metabolomic analysis was performed on individuals from each area with notable variations in glycogen content.After 10 months of culture,these differences were highly notable,with the maximum variations being in the multiples of 17.42 and 8.79,respectively.Compared with the high-glycogen group,189 and 361 dif-ferentially accumulated metabolites were identified in the low-glycogen groups from the two sea areas,respectively.The commonly enriched metabolic pathways included arachidonic acid metabolism,neuroactive ligand-receptor interaction,and the FOXO signaling pathway.In addition,the D-amino acid metabolism pathway was enriched in the specimens from Meizhou,while the glycerophospholipid metabolism pathway was enriched in the specimens from Shijing.C.angulata may affect glycogen content through multiple pathways:upregulating the expression of LXA4 to inhibit inflammatory response,reducing energy consumption,and promoting glycogen storage,enhancing gluconeogenesis and other processes through the D-amino acid and starch-sucrose metabolism pathways to produce more glucose for glycogen biosynthesis.This study provides basic data for the subsequent genetic improvement of glycogen-related traits in C.angulata.关键词
福建牡蛎/糖原含量/个体差异/非靶向代谢组学Key words
Crassostrea angulata/glycogen content/individual difference/nontargeted metabonomics分类
农业科技引用本文复制引用
张建敏,史博,王静,阙华勇,黄小青..两个海区福建牡蛎糖原相对高低群体代谢组差异分析[J].海洋科学,2026,50(2):37-50,14.基金项目
国家自然科学基金项目(32172979) （32172979）
漳州诏安水产养殖加工产业链科技特派团(2024N0057)[National Natural Science Foundation of China,No.32172979 （2024N0057）
Zhangzhou Zhaoan Aquaculture Processing Industry Chain Science and Technology Mission,No.2024N0057] （）
