摘要
Abstract
Objective To investigate the association between lymphocyte-to-high-density lipoprotein cholesterol ratio(LHR)and the prevalence of gallstone disease(GSD).Methods Data were drawn from the US National Health and Nutrition Examination Survey(NHANES)database between 2017 and 2020.Participants were divided into GSD group(n=848)and non-GSD group(n=7046)according to the GSD status.LHR was treated as the exposure variable,which was grouped into quartiles(Q1-Q4)to evaluate its association with GSD.A multivariate logistic regression model was used to analyze the relationship between LHR and the risk of GSD.Meanwhile,subgroup analyses and interaction tests were performed,and restricted cubic spline analysis was employed to assess the nonlinear associations.Results A total of 7894 participants were enrolled in this study,with a GSD prevalence of 10.74%.The median LHR was 1.57(interquartile range:1.13,2.14).Multivariate logistic regression analysis revealed a significant positive association between elevated LHR and the risk of GSD[fully adjusted model:odds ratio(OR)=1.20,95%CI 1.07-1.35,P=0.002].Compared with participants in the lowest quartile(Q1),those in the third quartile(Q3)had a 66%increased risk of GSD(OR=1.66,95%CI 1.30-2.10,P<0.001),while those in the fourth quartile(Q4)had a 46%increased risk(OR=1.46,95%CI 1.13-1.87,P=0.003).Subgroup analyses demonstrated that this association remained consistent across all subgroups,and there were significant interactions for gender and smoking status(Pinteraction<0.05).Furthermore,the findings were validated using an independent dataset of 255 participants from Beijing Chaoyang Hospital Affiliated to Capital Medical University.Restricted cubic spline(RCS)and threshold effect analyses suggested a nonlinear association between LHR and GSD(Pnon-linearity=0.022).Conclusions LHR is positively correlated with an increased risk of GSD,suggesting that LHR may serve as a simple and cost-effective tool for the early detection and management of individuals at high risk of GSD.关键词
胆结石/高密度脂蛋白胆固醇/淋巴细胞/高密度脂蛋白胆固醇比值/全国健康与营养调查/横断面研究Key words
gallstone disease/high-density lipoprotein cholesterol/lymphocyte-to-high-density lipoprotein cholesterol ratio/National Health and Nutrition Examination Survey(NHANES)/cross-sectional study分类
医药卫生
