经济动物学报2026，Vol.30Issue(4)：265-271,7.DOI:10.13326/j.jea.2026.2000
不同寄主来源的蜜蜂残翅病毒前导蛋白生物信息学分析
Bioinformatics Analysis of the Leader Protein of Deformed Wing Virus Strains from Different Hosts
摘要
Abstract
The leader protein of Deformed wing virus(DWV)was systematically investigated through integrative bioinformatics analysis using complete genome sequences from six phylogenetically diverse hosts of Apis mellifera,Medauroidea extradentata,Varroa destructor,Bougainvillea spectabilis Willdenow,Wisteria sinensis Sweet,and Jasminum nudiflorum Lindley.Despite high overall structural conservation,the leader protein exhibited distinct host-associated sequence variations that reshape predicted phosphorylation and glycosylation landscapes,as well as epitope profiles.These variations were predicted to alter post-translational regulation,subcellular targeting,and host-virus interface dynamics.Collectively,our results identified the DWV leader protein as a conserved yet functionally plastic determinant of viral adaptation,providing mechanistic insight into cross-species transmission.This work established a molecular framework for understanding host-specific viral evolution and highlights the leader protein as a promising target for antiviral intervention.关键词
蜜蜂残翅病毒/前导蛋白/生物信息学分析Key words
deformed wing virus/leader protein/bioinformatics analysis分类
农业科技引用本文复制引用
龚沛勋,王斌,董坤,张炫..不同寄主来源的蜜蜂残翅病毒前导蛋白生物信息学分析[J].经济动物学报,2026,30(4):265-271,7.基金项目
国家现代蜂产业技术体系项目(CARS-44-kxj13),云南省国际科技特派员项目(202203AK140020) （CARS-44-kxj13）
