经济动物学报2026，Vol.30Issue(4)：272-279,8.DOI:10.13326/j.jea.2026.2037
植物乳杆菌胞外囊泡对DSS诱导结肠炎的缓解作用
Alleviating Effects of Lactobacillus plantarum Extracellular Vesicles on DSS-Induced Colitis
摘要
Abstract
In order to explore the ameliorative effects of Lactobacillus plantarum extracellular vesicles(LpEVs)on colitis,extracellular vesicles extracted from L.plantarum of porcine source were administered to C57BL/6 mice at different concentrations,and then DSS was used to induce colitis model.The weight change rate of mice,the disease activity index,the length of the colon,the spleen index,and the pathological changes of the colon tissue were monitored,and the activity of myeloperoxidase in serum and the levels of inflammatory cytokines(IL-6,IL-1β and TNF-α)were detected by ELISA.The results showed that the body weight of DSS-induced colitis mice decreased,the DAI index increased,the colon shortened,the spleen index increased,the colon tissue was seriously damaged,the serum myeloperoxidase activity increased,and the expression levels of pro-inflammatory cytokines IL-6,IL-1β and TNF-α increased.After intervention with LpEVs,all the above indicators were improved,indicating that L.plantarum extracellular vesicles have a good alleviating effect on colitis.The research results provide a theoretical basis for exploring the mechanism by which probiotics alleviate colitis.关键词
植物乳杆菌/胞外囊泡/结肠炎/DSS模型/促炎因子Key words
Lactobacillus plantarum/extracellular vesicles/colitis/DSS model/inflammatory factors分类
农业科技引用本文复制引用
单心,胡静涛,张仕涵,屈广隆,孙安琪,汤正旭,仉鑫悦,吴丹妮,刘紫璇,王一冰..植物乳杆菌胞外囊泡对DSS诱导结肠炎的缓解作用[J].经济动物学报,2026,30(4):272-279,8.基金项目
吉林省科技发展计划项目(20240601058RC),国家自然科学基金项目(U21A20261,32273043),吉林省大学生创新创业训练计划项目(S202310193135,S202410193009) （20240601058RC）
