皮肤性病诊疗学杂志2026，Vol.33Issue(7)：505-511,7.DOI:10.3969/j.issn.1674-8468.2026.07.004
强脉冲光联合化学换肤对轻中度痤疮患者皮肤表观生理参数的影响
Effects of intense pulsed light combined with chemical peeling on skin surface physiological parameters in patients with mild to moderate acne
摘要
Abstract
Objective To investigate the effects of intense pulsed light(IPL)combined with chemical peeling on skin surface physiological parameters in patients with mild to moderate acne.Methods One hundred and twenty patients with mild to moderate acne who visited the Depart-ment of Dermatology at Emergency General Hospital from January 2024 to June 2025 were enrolled in this study.The cohort was randomly divided into three groups(40 patients per group):Group A received IPL only;Group B received chemical peeling only;and Group C received both IPL and chemical peeling.The treatment course lasted three months,with monthly intervals.The clinical efficacy,incidence of adverse reactions,and skin surface physiological parameters were compared among three groups.Results Group C achieved 100％effectiveness,while Group A and Group B were both 97.50％.However,there were no statistically significant differences in treatment effec-tiveness among the three groups(P=0.600).Before treatment,there were no significant differ-ences in surface pigment area,pore count,porphyrin count,or skin smoothness among the three groups of patients(F=0.22,0.05,0.16,0.17;P=0.804,0.952,0.856,0.847,respective-ly).After treatment,there were significant differences in surface pigment area,pore count,por-phyrin count,and skin smoothness among the three groups(F=8.92,3.48,25.44,28.38,re-spectively;P＜0.001,P=0.034,P＜0.001,P＜0.001,respectively).Further pairwise com-parisons showed that the surface pigment area in Group C was lower than that in Group A and Group B(t=3.69,3.62,respectively,both P＜0.001),the pore count in Group C was lower than that in Group A and Group B(t=2.28,2.29,respectively;P=0.025 and 0.024),the porphyrin count in Group C was lower than that in Group A and Group B(t=6.52 and 5.76,both P＜0.001),and the skin smoothness in Group C was higher than that in Group A and Group B(t=-6.09,-6.89,respectively,both P＜0.001).There was no significant difference in the incidence of adverse reactions among the three groups(P=0.857).Conclusions Intense pulsed light combined with chemical peeling can effectively improve the skin color of patients with mild to moderate acne,reduce the number of pores and porphyrin fluorescence intensity,and the effect is significant.关键词
痤疮/强脉冲光/化学换肤/毛孔数量/卟啉Key words
acne/intense pulsed light/chemical peeling/pore count/porphyrin引用本文复制引用
柴永丽,廉琛,刘爱英,朱晓如,刘晴云,伍艺佩..强脉冲光联合化学换肤对轻中度痤疮患者皮肤表观生理参数的影响[J].皮肤性病诊疗学杂志,2026,33(7):505-511,7.基金项目
应急总医院学科科技创新基金项目(KX202401) （KX202401）
