皮肤性病诊疗学杂志2026，Vol.33Issue(7)：527-535,9.DOI:10.3969/j.issn.1674-8468.2026.07.008
瘢痕治疗的临床进展
The advances in scar clinical treatment
摘要
Abstract
Scars represent a common outcome of aberrant tissue remodeling following wound healing.The hypertrophic scars and keloids cause pain,pruritus,cosmetic disfigurement,and functional impairment,which carry significant psychological and social consequences for patients.Scar management has shifted from single-modality treatment to a multidisciplinary strategy incorpo-rating risk stratification,early intervention,and multimodal therapy.We reviewed the recent pro-gresses in scar management including clinical guidelines,randomized controlled trials,silicone-based prevention,pressure therapy,tension-reduction techniques,intralesional corticosteroids,5-fluorouracil(5-FU),bleomycin,and botulinum toxin type A(BoNT-A),vascular and ablative laser therapy,laser-assisted drug delivery,surgery combined with adjuvant radiotherapy,and e-merging approaches such as regenerative medicine,exosomes,tissue engineering,and nano-ena-bled delivery et al.Current studies have shown that silicone,tension reduction,and pressure ther-apy are suitable for early prevention;the intralesional and energy-based therapies are suitable for active lesions;and the excision is not the only strategy because of the high recurrence risk.Future investigations are required for precision treatment guided by the standardized outcomes,patient-re-ported measures,long-term follow-up and molecular profiling.关键词
瘢痕/瘢痕疙瘩/增生性瘢痕/硅酮制剂/激光治疗/压力疗法/再生医学Key words
scar/keloid/hypertrophic scar/silicone preparation/laser therapy/pressure therapy/regenerative medicine引用本文复制引用
沈非凡,刘悦,宋金鹏,周金辉,司小强..瘢痕治疗的临床进展[J].皮肤性病诊疗学杂志,2026,33(7):527-535,9.基金项目
甘肃省自然科学基金(22JR5RA690) （22JR5RA690）
