南京中医药大学学报2026，Vol.42Issue(8)：1130-1137,8.DOI:10.14148/j.issn.1672-0482.2026.1130
基于风毒探讨糖尿病肾脏病病机演变及治疗策略
Exploring the Pathogenesis Evolution and Therapeutic Strategies of Diabetic Kidney Disease from the Perspective of Wind-Toxin
摘要
Abstract
Diabetic kidney disease(DKD),categorized as"kidney consumption"or"Xiaoke kidney disease"in traditional Chinese medicine,is primarily characterized by proteinuria and progressive renal impairment.Controlling severe proteinuria remains a major therapeutic challenge,often leading to relentless functional decline."Wind-toxin"serves as a crucial pathological product in the evolu-tion of DKD's pathogenesis,persisting throughout the course of the disease and exhibiting the characteristics of both"wind"pathogens(mobility and rapid change)and"toxin"pathogens(virulence and tenacious stagnation).In the early stage,internal heat is exuberant while wind-toxin remains latent;in the intermediate stage,various pathogens transform into wind,and wind-toxin runs rampant;in the late stage,turbid toxins are generated internally,and wind-toxin lingers persistently.Based on the dynamic evolutionary patterns of wind-toxin pathogenesis,this paper proposes a stage-specific treatment strategy:in the early stage,expel pathogens to prevent disease progression and intercept the illness at its onset;in the intermediate stage,utilize insect-based and vine-type medicinal agents to search out wind and unblock the collaterals;and in the late stage,resolve and disperse wind-toxin and turbid toxins while harmonizing the internal organs.This study systematically elucidates a theoretical framework for managing DKD from the wind-toxin perspective,thereby providing a novel strategy for pattern differentiation and treatment in clinical practice.关键词
糖尿病肾脏病/风毒/中医病机/动态演变/分期治疗Key words
diabetic kidney disease/wind-toxin/traditional Chinese medicine pathogenesis/dynamic evolution/stage-specific treatment分类
医药卫生引用本文复制引用
王艾月,吴瑞崧,黄国顺,周恩超..基于风毒探讨糖尿病肾脏病病机演变及治疗策略[J].南京中医药大学学报,2026,42(8):1130-1137,8.基金项目
国家自然科学基金面上项目(82474427) （82474427）
第三批江苏省中医药领军人才培养项目(SLJ0319) （SLJ0319）
江苏省研究生实践创新计划项目(SJCX25_0939) （SJCX25_0939）
江苏省中医院高峰人才项目(k2026yrc10) （k2026yrc10）
