南京中医药大学学报2026，Vol.42Issue(8)：1145-1152,8.DOI:10.14148/j.issn.1672-0482.2026.1145
芪黄固肾通络方治疗脾肾气虚、湿浊血瘀型非透析慢性肾脏病矿物质及骨代谢异常的临床研究
Clinical Study on Qihuang Gushen Tongluo Prescription for Chronic Kidney Disease-Mineral and Bone Disorder in Non-Dialysis Patients with Spleen-Kidney Qi Deficiency,Dampness Turbidity and Blood Stasis
摘要
Abstract
OBJECTIVE To observe the clinical efficacy of Qihuang Gushen Tongluo Prescription in treating non-dialysis pa-tients with chronic kidney disease-mineral and bone disorder(CKD-MBD)characterized by spleen-kidney qi deficiency,dampness tur-bidity and blood stasis,and to investigate its effect on serum fibroblast growth factor 23(FGF-23).METHODS Sixty-eight non-dialysis CKD-MBD patients with spleen-kidney qi deficiency,dampness turbidity and blood stasis were randomly divided into a con-trol group and an observation group(n=34 each).The control group received basic Western medical treatment,while the observation group received Qihuang Gushen Tongluo Prescription in addition to the basic treatment.One treatment course lasted 4 weeks,and both groups underwent two courses of treatment.Changes in renal function[blood urea nitrogen(BUN),serum creatinine(Scr),estimated glo-merular filtration rate(eGFR)],calcium-phosphorus metabolism[serum calcium(Ca),phosphorus(P),intact parathyroid hormone(i PTH)],FGF-23 levels,and TCM syndrome scores were compared before and after treatment;adverse reactions were also recorded.RESULTS After 8 weeks of treatment,levels of BUN,P,iPTH,and FGF-23,as well as total TCM syndrome scores,decreased signifi-cantly,while Ca levels increased significantly in both groups(P<0.05).In the observation group,Scr decreased significantly and eGFR increased significantly(P<0.05),with the observation group outperforming the control group(P<0.05).The total effective rates for CKD-MBD and TCM syndrome were 88.2%and 73.5%in the observation group,and 67.6%and 52.9%in the control group,respec-tively;the observation group showed superior results compared to the control group(P<0.05).No significant abnormalities in safety in-dicators were observed in either group before or after treatment,and no allergic reactions or serious adverse events occurred during the treatment period.CONCLUSION Qihuang Gushen Tongluo Prescription can significantly improve clinical symptoms in non-dialysis CKD-MBD patients presenting with spleen-kidney qi deficiency,dampness turbidity and blood stasis;it demonstrates a favor-able safety profile,and its mechanism may be associated with the downregulation of FGF-23 expression levels.关键词
芪黄固肾通络方/慢性肾脏病/矿物质代谢/骨代谢异常/钙磷代谢/成纤维细胞生长因子23/脾肾气虚/湿浊血瘀Key words
Qihuang Gushen Tongluo Prescription/chronic kidney disease/mineral metabolism/abnormal bone metabolism/cal-cium and phosphorus metabolism/fibroblast growth factor 23/spleen-kidney qi deficiency/dampness turbidity and blood stasis分类
医药卫生引用本文复制引用
郭柏村,王慧丽,高雨杉,韩佳瑞..芪黄固肾通络方治疗脾肾气虚、湿浊血瘀型非透析慢性肾脏病矿物质及骨代谢异常的临床研究[J].南京中医药大学学报,2026,42(8):1145-1152,8.基金项目
河南省中医药科学研究专项课题(20-21ZY1003,2025ZY2016) （20-21ZY1003,2025ZY2016）
2024年度河南省高等学校重点科研项目(24A360008) （24A360008）
河南省中医药拔尖人才培养项目专项课题(2019ZYBJ17) （2019ZYBJ17）
研究生科研创新能力提升计划(2025KYCX058) （2025KYCX058）
