内科理论与实践2026，Vol.21Issue(3)：211-216,6.DOI:10.16138/j.1673-6087.2026.03.02
冷冻球囊消融与电复律治疗初发持续性心房颤动疗效及安全性比较
Comparison of efficacy and safety between cryoballoon ablation and electrical cardioversion for treatment of first-episode persistent atrial fibrillation
摘要
Abstract
Objective To compare the efficacy and safety of cryoballoon ablation versus electrical cardioversion in patients with first-episode,untreated persistent atrial fibrillation.Methods Patients with first-episode persistent atrial fibrillation who received cryoballoon ablation or electrical cardioversion in our hospital were enrolled.Propensity score matching was applied to balance baseline characteristics,and a total of 70 patients with atrial fibrillation duration<1 year were finally included,with 35 in the cryoballoon group and 35 in the cardioversion group.The primary efficacy endpoint was the freedom from atrial fibrillation recurrence at 1 year post-procedure,and the safety endpoint was the incidence of major complications.Results The 1-year freedom from recurrence rate was significantly higher in the cryoballoon group than in the cardioversion group(76.6%vs.45.0%,P<0.05).No significant difference was observed between the 2 groups in the incidence of severe complications such as stroke or cardiac tamponade.Left atrial diameter was identified as an independent risk factor for recurrence after cryoballoon ablation(hazard ratio=1.319,P=0.046),whereas atrial fibrillation duration was an independent risk factor for recurrence after cardioversion(hazard ratio=1.131,P=0.037).Conclusions For patients with first-episode persistent atrial fibrillation,cryoballoon ablation is superior to electrical cardioversion in maintaining sinus rhythm,with a favorable safety profile.Left atrial diameter and atrial fibrillation duration are important predictors of recurrence after each treatment modality,which may help guide individualized clinical decision-making.关键词
心房颤动/电复律/冷冻球囊消融/倾向评分匹配Key words
atrial fibrillation/electrical cardioversion/cryoballoon ablation/propensity score matching分类
医药卫生引用本文复制引用
卫越,包阳扬,罗庆志,谢运,林长坚,张凝,金奇,凌天佑,吴立群..冷冻球囊消融与电复律治疗初发持续性心房颤动疗效及安全性比较[J].内科理论与实践,2026,21(3):211-216,6.基金项目
上海市卫生健康委员会科研项目(20224Y0028) （20224Y0028）
