肿瘤预防与治疗2026，Vol.39Issue(7)：601-608,8.DOI:10.3969/j.issn.1674-0904.2026.07.010
挥发性有机化合物分析与食管癌诊断的研究现状及进展
Research Status and Progress of Volatile Organic Compound Analysis and the Diagnosis of Esophageal Cancer
摘要
Abstract
Esophageal carcinoma is one of the major gastrointestinal malignancies threatening human health.Its early symptoms are atypical,and around 70%of patients are diagnosed at the middle and advanced stages,with a 5-year survival rate of less than 30%.Although traditional endoscopic biopsy is the gold standard,it has limitations such as high invasive-ness,low compliance and difficulty in repeated monitoring.In recent years,detection of volatile organic compounds(VOCs),featuring non-invasiveness,convenience and the ability to reflect tumor metabolic status in real time,has provided new ideas for early screening and efficacy evaluation of esophageal cancer.This review summarizes the diagnostic bottlenecks of esophageal malignancies and the latest advances in VOCs detection technologies for exhaled breath and body fluids.It also systematically elaborates on the research status and future prospects of VOCs application in esophageal cancer,so as to provide a reference for relevant research and development.关键词
食管癌/挥发性有机化合物/早期筛查诊断Key words
Esophageal cancer/Volatile organic com-pounds/Early screening and diagnosis分类
医药卫生引用本文复制引用
刘豪然,热西代·阿卜杜拉,杨晓军,李强,田博..挥发性有机化合物分析与食管癌诊断的研究现状及进展[J].肿瘤预防与治疗,2026,39(7):601-608,8.基金项目
This study was supported by grants from Chengdu Science and Technology Bureau(No.2024-YF05-01097-SN)and Wu Jieping Medical Foundation(No.320.6750.2025-28-8).成都市科技局重点研发支撑计划(编号:2024-YF05-01097-SN) （No.2024-YF05-01097-SN）
吴阶平医学基金会科研专项资助课题(编号:320.6750.2025-28-8) （编号:320.6750.2025-28-8）
