护理研究2026，Vol.40Issue(17)：3016-3022,7.DOI:10.12102/j.issn.1009-6493.2026.17.008
兔耳缘静脉留置导管相关性血栓形成的病理时间动态研究
Time-dependent pathological study on catheter-related thrombosis in rabbit marginal ear veins
摘要
Abstract
Objective:To investigate the dynamic histopathological evolution of catheter-related thrombosis(CRT)in rabbit marginal ear veins within 12-96 hours,and identify the critical time point for the initiation of thrombus organization.Methods:Fifty New Zealand rabbits were divided into five indwelling groups with catheter retention durations of 12 h,24 h,48 h,72 h and 96 h(8 rabbits per group,with an additional 2 puncture-only control rabbits for each group).Semi-quantitative scoring was performed to evaluate thrombus characteristics,inflammatory response and vascular injury after hematoxylin-eosin(HE)staining.Results:The incidence of CRT rose from 25.0%at 12 h to 100.0%at 96 h(P<0.001).Scores for thrombus area,composition and adhesion stability increased significantly over time(all P<0.05).The dominant inflammatory cell shifted from neutrophils to macrophages,and vascular injury progressed from endothelial denudation to elastic lamina rupture.The total thrombus score was positively correlated with the total inflammatory score(r=0.89,P<0.001).Conclusion:The pathological progression of CRT in rabbit marginal ear veins is time-dependent.The 48-hour time point may serve as a critical turning point for early thrombus organization and aggravated vascular injury,providing experimental histopathological evidence for determining the safe indwelling duration of peripheral intravenous catheters in clinical practice.关键词
静脉留置导管/导管相关性血栓/兔耳缘静脉/时间依赖/最佳留置时间/组织病理学Key words
peripheral intravenous catheter/catheter-related thrombosis/rabbit marginal ear vein/time-dependent/optimal retention time/histopathology引用本文复制引用
唐文帅,邓丽梅,于茜,叶梓轩..兔耳缘静脉留置导管相关性血栓形成的病理时间动态研究[J].护理研究,2026,40(17):3016-3022,7.基金项目
2025年度广西高校中青年教师科研基础能力提升项目,编号:2025KY0534 （）
2023年国家级大学生创新创业训练计划项目,编号:202310601027 （）
2024年广西壮族自治区级大学生创新训练计划立项项目,编号:S202410601147 （）
2020年度广西高校中青年教师科研基础能力提升项目,编号:2020KY12035 （）
