护理研究2026，Vol.40Issue(17)：3030-3036,7.DOI:10.12102/j.issn.1009-6493.2026.17.010
情绪波动差异调控脂质代谢影响结直肠癌风险的孟德尔随机化研究
Mendelian randomization study on effect of emotional swing differences regulating lipid metabolism on colorectal cancer risk
摘要
Abstract
Objective:To evaluate the bidirectional causal relationship between emotional swing and colorectal cancer using Mendelian randomization,and to test the causal regulatory effect of emotional swing on lipid metabolism.Methods:Using summary data from genome-wide association studies,we selected genetic variants associated with emotional swing,colorectal cancer,total cholesterol,and triglycerides as instrumental variables.A bidirectional Mendelian randomization design was applied to assess causal associations in both directions between emotional swing and colorectal cancer.The inverse variance weighted method served as the primary analysis,supplemented by weighted median and MR-Egger regression for sensitivity analysis.We also tested the individual effects of total cholesterol and triglycerides as potential mediators.Results:Forward causal analysis detected only a marginal negative association between emotional swing and colorectal cancer using inverse variance weighting(OR=0.981),suggesting insufficient robustness.Reverse causal analysis found no significant causal effect of colorectal cancer on emotional swing(OR=0.839).Further analysis revealed that emotional swing exerted opposite causal effects on the two lipid indicators:a negative causal relationship with total cholesterol(OR=0.688)and a positive causal relationship with triglycerides(OR=1.797),with stable results.Conclusion:There is no robust bidirectional causal relationship between emotional swing and colorectal cancer,but emotional swing participates in disease progression through differential regulation of total cholesterol and triglycerides.Given the potential value of medicinal and edible resources of Shanxi in intervening in the emotion-metabolism-cancer axis,we recommend incorporating lipid metabolism indicators into comprehensive colorectal cancer risk management and exploring pathways for industrializing non-nutrient components in community prevention and treatment.关键词
情绪波动/结直肠癌/三酰甘油/总胆固醇/孟德尔随机化/药食同源Key words
emotional swing/colorectal cancer/triglycerides/total cholesterol/Mendelian randomization/medicinal and edible homology引用本文复制引用
杜燕,卢言妹,李若兰,朱瑞芳..情绪波动差异调控脂质代谢影响结直肠癌风险的孟德尔随机化研究[J].护理研究,2026,40(17):3030-3036,7.基金项目
2025年度山西"大健康产业研究"专项研究(山西省社会科学界联合会专项项目),编号:SSKLJKZX2025039 （山西省社会科学界联合会专项项目）
