武警医学2026，Vol.37Issue(7)：595-599,604,6.DOI:10.3969/j.issn.1004-3594.2026.07.008
单克隆胃癌7抗原、胃泌素-17和糖类抗原19-9联合检测对胃癌的诊断价值
Diagnostic value of combined detection of monoclonal gastric cancer 7 antigen,gastrin-17 and glycan antigens 19-9 for gastric cancer
摘要
Abstract
Objective To investigate the diagnostic value of combined detection of monoclonal gastric cancer 7 antigen(MG7-Ag),gastrin-17(G-17)and carbohydrate antigen 19-9(CA19-9)for gastric cancer.Methods A retrospective analysis was conduc-ted on 262 patients with gastric diseases admitted to Shuyang Hospital of traditional Chinese Medicine Affiliated to Medical College of Yangzhou University from January 1,2022 to January 1,2024,including 74 cases of chronic non-atrophic gastritis(28.25%),62 cases of chronic atrophic gastritis(23.66%),42 cases of gastric ulcer(16.03%),43 cases of gastric intraepithelial neoplasia(16.41%),and 41 cases of gastric cancer(15.65%).Forty-one patients were randomly selected from each of the chronic non-atrophic gastritis,chronic atrophic gastritis,gastric intraepithelial neoplasia,and gastric cancer groups for further analysis.The differences in serum lev-els of MG7-Ag,G-17,and CA19-9 were illustrated.For different stages of disease progression,a binary logistic regression model was constructed for the combined diagnosis of the three indicators,and the predicted probability output by the model was used as the com-bined detection indicator.Receiver operating characteristic(ROC)curve analysis was performed to evaluate the diagnostic performance of individual and combined detection.Results The levels of MG7-Ag,G-17,and CA19-9 were significantly higher in the gastric canc-er group than those in the precancerous lesion group,and the differences were statistically significant(P<0.05).In gastric cancer di-agnosis,the combined test achieved an AUC of 0.970,significantly higher than the single test of MG7-Ag(0.909),G-17(0.680),and CA19-9(0.852)(P<0.05),with optimal sensitivity(97.6%)and specificity(87.8%).In precancerous lesion stages(chronic a-trophic gastritis and intraepithelial neoplasia),although combined de-tection did not significantly increase the AUC value,it improved the overall performance of sensitivity and specificity.Conclusions The combined detection of MG7-Ag,G-17,and CA19-9 has high value in the diagnosis of gastric cancer,and its diagnostic efficacy is superior to that of individual indicators.关键词
MG7-Ag/G-17/CA19-9/诊断/胃癌Key words
MG7-Ag/G-17/CA19-9/diagnosis/gastric cancer分类
医药卫生引用本文复制引用
孙营,汤玉蓉,张所山..单克隆胃癌7抗原、胃泌素-17和糖类抗原19-9联合检测对胃癌的诊断价值[J].武警医学,2026,37(7):595-599,604,6.基金项目
国家自然科学基金资助项目(HO303) （HO303）
