疑难病杂志2026，Vol.25Issue(8)：906-911,6.DOI:10.3969/j.issn.1671-6450.2026.08.003
外周血UCN2、CCL3水平与心律失常性心肌病合并心力衰竭患者预后的相关性分析
Analysis of the relationship between peripheral blood UCN2 and CCL3 levels and the prognosis of patients with arrhythmogenic cardiomyopathy complicated with heart failure
摘要
Abstract
Objective To investigate the association of peripheral blood urocortin-2(UCN2)and chemokine CC motif ligand 3(CCL3)levels with prognosis in patients with arrhythmogenic cardiomyopathy(ACM)complicated by heart failure(HF),and to evaluate their predictive value for adverse outcomes.Methods A total of 118 patients with ACM com-plicated by HF hospitalized in the Department of Cardiovascular Medicine,Xining First People's Hospital,Qinghai Province,from January 2020 to January 2024 were enrolled as the HF group,and 118 ACM patients without HF were selected as the control group.According to baseline New York Heart Association(NYHA)classification,patients in the HF group were divi-ded into class Ⅱ-Ⅲ(n=69)and class IV(n=49)subgroups.Based on 1-year follow-up outcomes,HF patients were further divided into a poor-prognosis subgroup(n=57)and a good-prognosis subgroup(n=60).Peripheral blood UCN2 and CCL3 levels were measured at admission.Multivariate logistic regression was used to identify factors associated with poor prognosis in ACM patients with HF.Receiver operating characteristic(ROC)curve analysis was performed to evaluate the predictive va-lue of UCN2 and CCL3 for adverse outcomes.Results Peripheral blood UCN2 and CCL3 levels were significantly higher in the HF group than in the non-HF group(t/P=11.632/<0.001,12.678/<0.001).Patients in the NYHA class IV subgroup had significantly higher UCN2 and CCL3 levels than those in the class Ⅱ-Ⅲ subgroup(t/P=7.276/<0.001,6.326/<0.001).The poor-prognosis subgroup showed significantly higher UCN2 and CCL3 levels than the good-prognosis subgroup(t/P=8.836/<0.001,9.963/<0.001).Left ventricular ejection fraction(LVEF)<30%,elevated UCN2,and elevated CCL3 were identified as independent risk factors for poor prognosis in ACM patients with HF[OR(95%CI)=2.044(1.221-3.423),1.362(1.031-1.799),and 1.115(1.005-1.237)].The AUCs of UCN2,CCL3,and their combination for predicting poor prognosis were 0.818,0.812,and 0.910,respectively,with the combined model showing significantly superior predictive performance compared with either biomarker alone(Z=2.285,2.128;P=0.003,0.005).Conclusion Peripheral blood UCN2 and CCL3 levels are elevated in ACM patients with HF and are associated with HF progression and adverse outcomes.Combined detec-tion of UCN2 and CCL3 provides important predictive value for prognosis.关键词
心律失常性心肌病/心力衰竭/尿皮质素2/趋化因子CC基序配体3/预后Key words
Arrhythmogenic cardiomyopathy/Heart failure/Urocortin-2/Chemokine CC motif ligand 3/Prognosis分类
医药卫生引用本文复制引用
常彩莲,史岩,马延海,李宝坤,吴静..外周血UCN2、CCL3水平与心律失常性心肌病合并心力衰竭患者预后的相关性分析[J].疑难病杂志,2026,25(8):906-911,6.基金项目
青海省科技计划项目(2022-ZJ-729) Qinghai Provincial Science and Technology Program Project(2022-ZJ-729) （2022-ZJ-729）
