疑难病杂志2026，Vol.25Issue(8)：923-927,5.DOI:10.3969/j.issn.1671-6450.2026.08.006
血清8-iso-PGF2α、C5a联合评估儿童心肌炎心肌损伤及预后的价值
Serum 8-iso-PGF2α and C5a joint ealuation of myocardial injury and prognosis in children with myocarditis
摘要
Abstract
Objective To investigate the combination of serum 8-iso-prostaglandin F2α(8-iso-PGF2α)and comple-ment component 5a(C5a)in evaluating myocardial injury and prognosis in children with myocarditis(MC).Methods A total of 120 children with MC(MC group)admitted to the Department of Cardiovascular and Rheumatology of Shanxi Chil-dren's Hospital(Shanxi Maternal and Child Health Hospital)from January 2021 to June 2024 were prospectively selected,and 120 healthy children(healthy control group)were selected at a 1∶1 ratio.Serum 8-iso-PGF2α and C5a levels were detected by enzyme-linked immunosorbent assay.Myocardial injury markers[cardiac troponin I(cTnI),creatine kinase isoenzyme MB(CK-MB)]were measured by paramagnetic particle chemiluminescence immunoassay.Pearson correlation analysis was used to analyze the correlation between serum 8-iso-PGF2α,C5a,and myocardial injury markers in children with MC.Factors in-fluencing prognosis and the efficacy of serum 8-iso-PGF2α and C5a levels in evaluating poor prognosis in children with MC were analyzed.Results Compared with the healthy control group,serum levels of 8-iso-PGF2α,C5a,cTnI,and CK-MB were significantly higher in the MC group(t=14.759,16.801,29.383,14.007,all P<0.001).Serum 8-iso-PGF2α and C5a le-vels in children with MC were positively correlated with cTnI and CK-MB levels(r=0.708,0.699,0.637,0.625,all P<0.001).The 1-year poor prognosis rate among the 120 children with MC was 26.67%(32/120).Levels of C-reactive protein(CRP),cTnI,CK-MB,8-iso-PGF2α,and C5a were significantly higher in the poor prognosis subgroup than in the good prognosis subgroup(t=2.395,2.295,2.341,2.993,5.707,all P<0.05).Elevated CRP,elevated cTnI,elevated CK-MB,elevated 8-iso-PGF2α,and elevated C5a were independent risk factors for poor prognosis in children with MC[OR(95%CI)=2.657(1.366-5.165),4.658(1.672-12.982),1.228(1.051-1.435),1.047(1.024-1.070),1.055(1.027-1.083)].The AUCs of serum 8-iso-PGF2α,C5a,and their combination in evaluating poor prognosis in children with MC were 0.795,0.806,and 0.905,respectively.The combined detection was superior to each individual marker(Z=3.198,2.683;P=0.001,0.007).Conclusion Elevated serum 8-iso-PGF2α and C5a levels are associated with aggravated myocardial injury and poor prognosis in chil-dren with myocarditis.Combined detection of serum 8-iso-PGF2α and C5a provides higher predictive value for prognosis assessment.关键词
心肌炎/心肌损伤/8-异前列腺素F2α/补体成分5a/预后/儿童Key words
Myocarditis/Myocardial injury/8-iso-prostaglandin F2α/Complement component 5a/Prognosis/Children分类
医药卫生引用本文复制引用
孙晶,杨蕊华,孙晔,刘丽华,崔涛..血清8-iso-PGF2α、C5a联合评估儿童心肌炎心肌损伤及预后的价值[J].疑难病杂志,2026,25(8):923-927,5.基金项目
山西省卫生健康科研课题(2022047) Shanxi Province Health Research Project(2022047) （2022047）
