疑难病杂志2026，Vol.25Issue(8)：939-944,6.DOI:10.3969/j.issn.1671-6450.2026.08.009
阿利西尤单抗在老年他汀不耐受脑梗死合并高脂血症中的应用及对神经功能和预后的影响
Application of alirocumab in elderly patients with cerebral infarction complicated by hyperlipidemia intolerant to statins,and its impact on neurological function and prognosis
摘要
Abstract
Objective To investigate the efficacy of alirocumab combined with neurointerventional therapy in treating elderly patients with cerebral infarction complicated by hyperlipidemia who are intolerant to statins.Methods A total of 86 elderly patients with cerebral infarction complicated by hyperlipidemia who were intolerant to statins and admitted to the Department of Neurology,General Hospital of Taiyuan Iron and Steel(Group)Co.,Ltd.from January 2020 to August 2024 were retrospectively selected.They were divided into a conventional group and a combined group according to different treat-ment regimens,with 43 cases in each group.Both groups received basic treatment.The conventional group additionally re-ceived neurointerventional therapy,while the combined group received alirocumab combined with neurointerventional therapy.Therapeutic efficacy,adverse reactions,as well as lipid profiles,hemorheology,neurological function scores,prognosis scores,and activities of daily living scores before and after treatment were compared between the two groups.Results The total ef-fective rate in the combined group was significantly higher than that in the conventional group(χ2=4.914,P=0.027).After 12 weeks of treatment,levels of TC,TG,LDL-C,ApoA1,and ApoB decreased,while HDL-C increased in both groups,with more pronounced changes in the combined group(t=3.989,5.946,4.979,6.014,5.087,4.977,all P<0.001).The combined group had significantly lower levels of FIB,plasma viscosity,whole blood high-shear viscosity,and whole blood low-shear viscosity than the conventional group(t=4.851,5.902,4.186,4.486,all P<0.001).NIHSS and mRS scores decreased,while MBI scores increased in both groups,with more marked improvements in the combined group(t=5.164,8.962,4.387,all P<0.001).No significant difference was observed in the incidence of adverse reactions between the two groups(P>0.05).Con-clusion The combination of alirocumab and neurointerventional therapy demonstrates significant efficacy in elderly patients with cerebral infarction complicated by hyperlipidemia who are intolerant to statins.It can improve lipid metabolism and he-morheology,reduce neurological impairment,enhance prognosis,and improve activities of daily living.关键词
脑梗死/高脂血症/阿利西尤单抗/神经介入治疗/阿托伐他汀/血脂/神经功能评分/疗效Key words
Cerebral infarction/Hyperlipidemia/Alirocumab/Neurointervention/Atrovastatin/Blood lipids/Neuro-logical function score/Therapeutic effect分类
医药卫生引用本文复制引用
陈彦军,孙博,张龙兴,孔瑜,吴雪梅..阿利西尤单抗在老年他汀不耐受脑梗死合并高脂血症中的应用及对神经功能和预后的影响[J].疑难病杂志,2026,25(8):939-944,6.基金项目
山西省应用基础研究计划项目(202103021224449) Shanxi Provincial Basic Research Program Project(202103021224449) （202103021224449）
