马旭东 1张俊阳 1杨梦 1郝志友 1郑晓珂 1冯卫生1
作者信息
- 1. 河南中医药大学药学院,河南 郑州 450046||河南省中药开发工程技术研究中心,河南 郑州 450046
- 折叠
摘要
Abstract
Objective To systematically investigate the chemical constituents of 70%acetone extract of Polygonatum cyrtonema processed by nine cycles of steaming and sun-drying.Method Compounds were isolated and purified by MCI gel,silica gel,Toyopearl HW-40C,ODS and semi-preparative HPLC.Their chemical structures were comprehensively elucidated by spectroscopic methods,such as HRESIMS,NMR,IR,UV and ECD.Results A total of 14 nitrogen-containing compounds were finally isolated and identified as 6-[(8R,9S)-8,9,10-trihydroxybutyl]-3,4-dimethylpyridazine(1),6-ethyl-3-(hydroxymethyl)-1H-pyridin-2-one(2),(+)-(1R,3R)-1-methyl-1,2,3,4-tetrahydro-β-carboline-3-carboxylic acid(3),1H-indole-3-carboxaldehyde(4),cyclo-(L-Leu-L-Phe)(5),cyclo-(L-Phe-L-Ile)(6),cyclo-(L-Asn-L-Phe)(7),(3S,6S)-3-benzyl-6-(1-hydroxyethyl)-2,5-piperazinedione(8),cyclo-(D-Phe-Gly)(9),cyclo-(L-Tyr-L-Tyr)(10),cyclo-(L-Val-L-Tyr)(11),pedatisectine L(12),cyclo-(Ala-Tyr)(13),and(2S,5S)-5-[(1S)-1-methylpropyl]-3,6-dioxo-2-piperazinepropanoic acid(14).Conclusion Compounds 1 and 2 were characterized as two new compounds named cyrtoneine J and cyrtoneine K,while compounds 3 and 5-14 were isolated from the genus Polygonatum for the first time.关键词
多花黄精/炮制/含氮类/环(L-亮氨酸-L-苯丙氨酸)/多花黄精碱 J/多花黄精碱 KKey words
Polygonatum cyrtonema Hua./processing/nitrogen-containing/cyclo-(L-Leu-L-Phe)/cyrtoneine J/cyrtoneine K分类
医药卫生
