中国癌症杂志2026，Vol.36Issue(7)：686-692,7.DOI:10.19401/j.cnki.1007-3639.2026.07.008
自然杀伤细胞在卵巢癌免疫治疗中的研究现状及展望
Research progress and future perspectives of natural killer cells in ovarian cancer immunotherapy
摘要
Abstract
Ovarian cancer remains the most lethal gynecologic malignancy.Although cytoreductive surgery and platinum-paclitaxel combination chemotherapy as first-line treatment have improved outcomes for a subset of patients,the majority eventually develop platinum-resistant recurrence,underscoring the urgent need for novel therapeutic strategies to achieve durable disease control.Recent advances in natural killer(NK)cell-based immunotherapy have demonstrated substantial potential for ovarian cancer treatment,capitalizing on the potent cytotoxicity and favorable safety profile of NK cells.This review systematically discusses how the ovarian cancer tumor microenvironment(TME)impairs NK-cell function through enrichment of inhibitory cytokines,metabolic reprogramming,and overexpression of inhibitory immune checkpoints on the NK-cell surface.It then focuses on current therapeutic strategies and their clinical development,including cytokine-based therapies,chimeric antigen receptor-NK(CAR-NK)cells and NK cell engagers(NKCEs).We further summarize the landscape of completed and ongoing clinical trials involving NK-cell-based immunotherapy for ovarian cancer,and discuss future directions for rational combination strategies,so as to provide updated insights to optimize NK cell-based immunotherapeutic approaches.关键词
卵巢肿瘤/自然杀伤细胞/免疫治疗/肿瘤微环境/嵌合抗原受体Key words
Ovarian cancer/Natural killer cells/Immunotherapy/Tumor microenvironment/Chimeric antigen receptor分类
医药卫生引用本文复制引用
陈田,刘海鸥,陆佳琦..自然杀伤细胞在卵巢癌免疫治疗中的研究现状及展望[J].中国癌症杂志,2026,36(7):686-692,7.基金项目
国家自然科学基金(82473274). National Natural Science Foundation of China(82473274). （82473274）
