中国当代儿科杂志2026，Vol.28Issue(8)：916-921,6.DOI:10.7499/j.issn.1008-8830.2601183
儿童呼吸系统疾病合并生长障碍的研究进展
Advances in growth impairment associated with pediatric respiratory diseases
摘要
Abstract
Pediatric respiratory diseases are significantly associated with growth impairment.Through core pathways including chronic hypoxia,systemic inflammation,metabolic dysregulation,and pharmacological interference,these conditions suppress the growth hormone-insulin-like growth factor axis and peripheral signaling,resulting in growth retardation.This article summarizes mechanistic advances regarding growth impairment in obstructive sleep apnea,asthma,chronic lung injury,and recurrent respiratory infections.Accordingly,it discusses intervention strategies encompassing growth monitoring,etiology-targeted therapy,and the standardized use of growth hormone,while highlighting differences from the management of idiopathic short stature.The aim is to elucidate the underlying pathophysiology and provide evidence to optimize clinical management and improve growth outcomes.关键词
生长障碍/呼吸系统疾病/儿童Key words
Growth disorder/Respiratory disease/Child引用本文复制引用
陈晓雯,陈德晖..儿童呼吸系统疾病合并生长障碍的研究进展[J].中国当代儿科杂志,2026,28(8):916-921,6.基金项目
广州医科大学科研能力提升计划重大临床研究一般培育项目(GMUCR2024-02008). （GMUCR2024-02008）
