中国当代儿科杂志2026，Vol.28Issue(8)：966-971,6.DOI:10.7499/j.issn.1008-8830.2511078
单中心儿童静脉血栓性疾病40例临床特征及诊治分析
Clinical characteristics,diagnosis,and treatment of 40 cases of venous thrombotic disease in children at a single center
摘要
Abstract
Objective To investigate the clinical characteristics,diagnostic approach,multidisciplinary diagnosis and treatment model,and anticoagulation strategies of venous thrombotic disease in children,summarize diagnosis and treatment experience,and provide a reference for improving standardized management of this condition.Methods A retrospective analysis was conducted on clinical data of 40 children with venous thrombotic disease managed by the multidisciplinary team(MDT)at Shenzhen Children's Hospital.Data included demographic characteristics,underlying diseases,risk factors,clinical manifestations,diagnostic procedures,anticoagulation regimens,and clinical outcomes.Results Among the 40 children,the most common risk factor was central venous catheter placement(42%),and the most frequent underlying diseases were malignant tumors(30%)and severe infections(25%).Clinical manifestations were diverse and often insidious,frequently masked by primary diseases.All cases were confirmed by imaging examinations.Anticoagulation mainly involved low-molecular-weight heparin and warfarin,with some patients receiving oral anticoagulants.Following MDT management and individualized anticoagulation therapy,the overall recanalization rate was 98%,the incidence of bleeding was 5%,and no major bleeding events occurred.Conclusions Venous thrombotic disease in children commonly occurs secondary to severe underlying conditions and presents with atypical clinical features,requiring increased diagnostic vigilance.A diagnosis and treatment model centered on an MDT,combined with individualized anticoagulation therapy,effectively improves prognosis and represents an effective strategy for managing these complex cases.关键词
静脉血栓性疾病/多学科治疗协作组/抗凝治疗/儿童Key words
Venous thrombotic disease/Multidisciplinary team/Anticoagulant therapy/Child引用本文复制引用
李倩,冯雪,林荣波,陈黎,刘麟,车东方,李振锋,梁振江,朱理想,魏锋,文飞球,王缨,周桂池,张宇聪,孙龙伟,李志惠,谢淦,付笑迎..单中心儿童静脉血栓性疾病40例临床特征及诊治分析[J].中国当代儿科杂志,2026,28(8):966-971,6.基金项目
深圳市医疗卫生"三名工程"(SZSM202211033) （SZSM202211033）
广东省高水平临床重点专科(SZGSP012) （SZGSP012）
深圳市医学重点学科建设经费资助(SZXK034). （SZXK034）
