中国肛肠病杂志2026，Vol.46Issue(7)：1-6,6.
基于网络药理学与分子技术探讨蒙药巴特日-7味丸治疗溃疡性结肠炎的作用机制
Mechanism of Mongolian Medicine Bateri-Qiwei Pills in Treatment of Ulcerative Colitis Based on Net-work Pharmacology and Molecular Technology
摘要
Abstract
Objective To investigate the material basis and mechanism of Mongolian medicine Bateri-Qiwei Pills in the treatment of ulcerative colitis using network pharmacology and molecular docking technology.Methods Medicinal components,drug targets and disease targets of Bateri-Qiwei Pills were screened out by combining published literature and multiple databases including TCMSP,SwissTargetPrediction,ETCM,GeneCards and DISGENET.Venny 2.1.0 was used to find the intersection of the action targets of Bateri-Qiwei Pills in the treatment of ulcerative colitis.Protein-protein interaction(PPI)network of candidate targets was constructed via the STRING platform.GO functional enrichment analysis and KEGG pathway annotation were performed based on the David database.Cytoscape 3.9.1 software was applied to establish the active component-target-signal pathway network,so as to screen the pivotal active components,core targets and key signaling pathways.Results Network pharmacological analysis demonstrated that the core active ingredients of Bateri-Qiwei Pills in the treatment of ulcerative colitis included Morin,Pinocembrin,17-Hydroxy-10,13-Dimethyl-1,2,6,7,8,9,11,12,14,15,16,17-Dodecahydrocyclopenta[A]Phenanthren-3-One,(R)-(6-methoxy-4-quinolyl)-[(2R,4R,5S)-5-vinylquinuclidin-2-yl]methanol and Cheilanthifoline.Core thera-peutic targets contained AKT1,TNF,GAPDH,IL-6 and IL1B.Molecular docking verified the binding activ-ity between pharmacodynamic components and core targets of Bateri-Qiwei Pills.Conclusion Mongolian medicine Bateri-Qiwei Pills exerts therapeutic effects on ulcerative colitis through the synergistic action of multi-components,multi-targets and multi-signaling pathways.关键词
溃疡性结肠炎/蒙药/巴特日-7味丸/网络药理学/分子对接Key words
Ulcerative colitis/Mongolian medicine/Bateri-Qiwei Pills/Network pharmacology/Molecu-lar docking引用本文复制引用
春花,王磊,宝音图..基于网络药理学与分子技术探讨蒙药巴特日-7味丸治疗溃疡性结肠炎的作用机制[J].中国肛肠病杂志,2026,46(7):1-6,6.基金项目
内蒙古自治区卫生健康委员会2022年度自治区卫生健康科技计划项目(编号:202201599) （编号:202201599）
内蒙古自治区科技计划项目(编号:2022YFSH0003) （编号:2022YFSH0003）
呼伦贝尔市科技局社会发展领域项目(编号:SF2021007) （编号:SF2021007）
2024年度呼伦贝尔市基础研究和应用基础研究领域项目(编号:GH2025006) （编号:GH2025006）
