中国临床药理学杂志2026，Vol.42Issue(12)：1692-1696,5.DOI:10.13699/j.cnki.1001-6821.2026.12.007
盐酸氮(艹卓)斯汀鼻喷雾剂联合布地奈德治疗变应性鼻炎患者的临床研究
Clinical trial of azelastine hydrochloride nasal spray combined with budesonide for the treatment of allergic rhinitis
摘要
Abstract
Objective To explore the clinical efficacy of nasal spray of azelastine hydrochloride combined with budesonide in the treatment of allergic rhinitis(AR).Methods The AR patients were divided into the control group and the treatment group according to the random number table method.The control group was given budesonide nasal spray at a fixed dose of 256 μg per day,with 64 μg sprayed into each nostril per time,twice a day.The treatment group was given azelastine hydrochloride nasal spray on the basis of the control group,with a fixed dose of 400 μg per day,twice a day,with 100 μg sprayed into each nostril per time.Both groups of patients received continuous treatment for one month.Compare the clinical efficacy,serum(EOS)and(IFN-γ),inflammatory factor interleukin-17(IL-17),IL-4,IL-18 index levels,total nasal symptom score scale(TNSS)score of the two groups,and conduct a safety evaluation.Results A total of 180 cases were included,with 90 cases in the control group and 90 cases in the treatment group.After the treatment,the total effective rates of the treatment group and the control group were 97.78％(88 cases/90 cases)and 90.00％(81 cases/90 cases),respectively.The difference was statistically significant(P＜0.05).After treatment,the eosinophil(EOS)levels of the treatment group and the control group were(4.33±0.47)× 109·L-1 and(5.18±0.58)× 109·L-1 respectively,the IL-4 levels were(4.36±0.49)and(5.05±0.55)μg·L-1 respectively;the IL-17 levels were(18.44±1.93)ng·L-1 and(23.97±2.91)ng·L-1,respectively;the IL-18 levels were(122.67±12.67)and(149.83±15.84)ng·L-1,respectively,and the TNSS scores were(3.76±0.43)points and(5.27±0.59)points,respectively;the levels of IFN-γ were(83.29±8.49)and(75.12±7.65)mg·L-1,respectively.Compared with the control group,the above indicators in the treatment group showed statistically significant differences in both cases(all P＜0.001).The total incidence rates of adverse drug reactions in the treatment group and the control group were 6.67％(6 cases/90 cases)and 4.44％(4 cases/90 cases),respectively.There was no statistical significance in this regard(P＞0.05).Conclusion The combination of azelastine hydrochloride nasal spray and budesonide nasal spray has a significant therapeutic effect on AR.It can improve serum EOS and IFN-γ levels,alleviate clinical symptoms and inflammatory reactions in patients,and has favorable safety.关键词
盐酸氮(艹卓)斯汀鼻喷雾剂/布地奈德鼻喷雾剂/变应性鼻炎/血清嗜酸粒细胞/γ-干扰素Key words
azelastine hydrochloride nasal spray/budesonide nasal spray/allergic rhinitis/serum eosinophils/γ-interferon分类
医药卫生引用本文复制引用
李丽莉,薄少军,王岳衡,张晶..盐酸氮(艹卓)斯汀鼻喷雾剂联合布地奈德治疗变应性鼻炎患者的临床研究[J].中国临床药理学杂志,2026,42(12):1692-1696,5.基金项目
北京市医院管理中心课题基金资助项目(2021031) （2021031）
