中国临床药学杂志2026，Vol.35Issue(6)：531-537,7.DOI:10.19577/j.1007-4406.2026.06.009
抗血管生成靶向药物致药物性高血压的影响因素
Analysis of influencing factors for drug-induced hypertension induced by antiangiogenesis targeted drugs
摘要
Abstract
AIM To analyze the influencing factors of drug-induced hypertension induced by anti-angiogenesis targeted drugs(ATD).METHODS Using a prospective study design,964 non-hypertensive patients treated with ATD in a hospital from December 2023 to August 2024 were enrolled.Patients' gender,age,tumor type,ATD type,diet,activity,anxiety and depression levels,and behavior types were collected.Through the follow-up of blood pressure twice a week,according to the diagnostic criteria of hypertension in the Chinese Guidelines for the Prevention and Treatment of Hypertension(2024 Revision),291 patients with drug-induced hypertension were selected as the hypertension group,and the remaining 673 patients without drug-induced hypertension were selected as the non-hypertension group.RESULTS Binary logistic regression analysis showed that gender,occupation,body mass index(BMI),diet taste,activity,sleep status,physical anxiety and depression levels,ATD category,and tumor type were the risk factors for ATD-induced hypertension.Males,individuals with a high BMI,those who were less physically active,those with sleep disorders,those experiencing anxiety,bevacizumab users,individuals with a type A personality,and patients diagnosed with digestive system tumors were more prone to ATD-related drug-induced hypertension.Conversely,self-employed individuals,retirees,unemployed individuals,and those experiencing higher levels of depression were less likely to develop drug-induced hypertension.CONCLUSION The occurrence of ATD-induced drug-related hypertension is influenced by multiple factors,suggesting that key populations should undergo pre-medication risk screening and prioritized intervention for modifiable factors during treatment.Throughout the medication process,it is essential not only to closely monitor patients' blood pressure but also to pay attention to their psychological status.By integrating patients' medication and disease characteristics,personalized and targeted blood pressure management plans should be developed to ensure medication safety.关键词
抗血管生成靶向药物/药物性高血压/危险因素/用药安全/不良反应Key words
anti-angiogenesis targeted drug/drug-induced hypertension/risk factor/medication safety/adverse reaction分类
医药卫生引用本文复制引用
龚航,陆箴琦,吴洪斌,李雅群,杨瑒,王伟英,许晨..抗血管生成靶向药物致药物性高血压的影响因素[J].中国临床药学杂志,2026,35(6):531-537,7.基金项目
2024年上海市护理学会科研课题(编号2024MS-B04) （编号2024MS-B04）
