中国美容医学2026，Vol.35Issue(8)：7-12,6.
玉仁雪白乳膏对黄褐斑模型小鼠皮肤"神经-内分泌-免疫"小网络功能的影响
Effects of Yuren Snow-white Cream on the Function of Skin"Neuro-endocrino-immune"Small Network in Mouse Model of Melasma
摘要
Abstract
Objective To investigate the effect mechanism of Yuren snow-white cream on the function of"neuro-endocrine-immune"small network in the skin of mouse model of melasma.Methods Forty female ICR mice were randomly divided into blank group,model group,10%Yuren snow-white cream group,20%Yuren snow-white cream group and centella asiatica ointment group,with 8 mice in each group.The mouse model of melasma was prepared by intramuscular injection of progesterone combined with 315 nm UVB irradiation.The blank group and the model group were evenly coated with sterilized water for injections on the skin of the molding area,and the 10%Yuren snow-white cream group,20%Yuren snow-white cream group and centella asiatica ointment group were respectively applied with 1 ml ointment to the skin of the molding area,and were administered once a day for 30 days.After the treatment,the pigmentation of the skin and the pathological changes of skin tissue were observed and recorded.The nervous system-related factors nitric oxide(NO)and stem cell factor(SCF)and the expression of endocrine related factors vascular endothelial growth factor(VEGF),α-melanocyte-stimulating hormone(α-MSH)and immune related factors interleukin-6(IL-6)and interleukin-10(IL-10)were detected by ELISA.Results Yuren snow-white cream can improve the pigmentation of mouse model of melasma.Compared with blank group,NO,SCF and α-MSH in model group were significantly increased(P＜0.05).Compared with model group,SCF in 10%Yuren snow-white cream group,centella asiatica ointment group and 20%Yuren snow-white cream group were decreased(P＜0.05).VEGF,α-MSH and IL-6 in 10%and 20%Yuren snow-white cream groups were significantly decreased(P＜0.05).IL-10 in 10%Yuren snow-white cream group was decreased(P＜0.05).Conclusion Yuren snow-white Cream has a good therapeutic effect on mouse model of melasma,and its mechanism may be related to the regulation of the"neuroendocrine-immune"small network of the local skin of mouse model of melasma.关键词
黄褐斑/玉仁雪白乳膏/皮肤"神经-内分泌-免疫"小网络Key words
melasma/Yuren snow-white Cream/skin"neuro-endocrino-immune"small network分类
医药卫生引用本文复制引用
张娟娟,吴淑辉,王艳,朱明芳..玉仁雪白乳膏对黄褐斑模型小鼠皮肤"神经-内分泌-免疫"小网络功能的影响[J].中国美容医学,2026,35(8):7-12,6.基金项目
长沙市自然科学基金(编号:kq2208497) （编号:kq2208497）
