中国免疫学杂志2026，Vol.42Issue(8)：1815-1820,6.DOI:10.3969/j.issn.1000-484X.2026.08.004
枸橼酸托法替布片联合艾拉莫德治疗类风湿关节炎的效果及对IL-21/STAT3信号通路的影响
Effect of tofacitinib citrate tablets combined with iguratimod in treatment of rheumatoid arthritis and its influence on IL-21/STAT3 signaling pathway
摘要
Abstract
Objective:To investigate the efficacy of tofacitinib citrate tablets combined with iguratimod in treatment of rheuma-toid arthritis(RA),and to analyze its effects on clinical symptoms and signs,inflammatory response,IL-21/STAT3 signaling pathways.Methods:A total of 110 patients with RA who were treated at the Fifth Affiliated Hospital of Zhengzhou University from January 2022 to September 2023 were were selected and divided into control group and observation group,with 55 cases in each group.Control group received iguratimod combined with methotrexate,while observation group received tofacitinib citrate tablets combined with iguratimod and methotrexate for 12 consecutive weeks.Therapeutic efficacy and improvements in clinical symptoms before and after treatment were compared between the two groups.Furthermore,serum IL-21/STAT3 signaling pathway factors(IL-21,p-STAT3,STAT3),inflammatory indexes,bone metabolism indexes,and adverse reactions were assessed.Results:Total effective rate of observation group was 94.55%,which was higher than that of control group(80.00%)(P<0.05).After treatment,morning stiffness duration,number of swollen joints,number of tender joints,and VAS score in observation group were significantly lower than those in control group(P<0.05).Serum levels of IL-21,p-STAT3 and STAT3 in observation group were also lower than those in control group after treatment(P<0.05).Furthermore,observation group exhibited lower levels of ESR,serum RF,CRP and TNF-α(P<0.05),higher levels of serum N-terminal mid-molecule osteocalcin(N-MID)and total type Ⅰ procollagen amino-terminal propeptide(TPⅠNP),and lower level of β-C-terminal telopeptide of type Ⅰ collagen(β-CTX)compared to control group(P<0.05).There was no significant difference in adverse reactions rate between the two groups(P>0.05).Conclusion:Combination of tofacitinib citrate tablets and iguratimod for treating RA patients improves clinical efficacy,alleviates clinical symptoms and pain,suppresses inflammatory responses,and ameliorates bone metabolism,with acceptable safety.Its therapeutic mechanism may be associated with the inhibition of IL-21/STAT3 signaling pathway.关键词
类风湿关节炎/枸橼酸托法替布片/艾拉莫德/疗效/骨代谢/炎症因子Key words
Rheumatoid arthritis/Tofacitinib citrate tablets/Iguratimod/Curative effect/Bone metabolism/Inflammatory factor分类
医药卫生引用本文复制引用
任丽丽,韩田,孟洋,丁艳霞..枸橼酸托法替布片联合艾拉莫德治疗类风湿关节炎的效果及对IL-21/STAT3信号通路的影响[J].中国免疫学杂志,2026,42(8):1815-1820,6.基金项目
河南省医学科技攻关计划联合共建项目(LHGJ20190062). （LHGJ20190062）
