中国普通外科杂志2026，Vol.35Issue(6)：1161-1172,12.DOI:10.7659/j.issn.1005-6947.260032
基于UK Biobank的C-反应蛋白-甘油三酯-葡萄糖指数与腹主动脉瘤发病风险的前瞻性队列研究
Association of the C-reactive protein-triglyceride-glucose index with incident abdominal aortic aneurysm:a prospective cohort study from the UK Biobank
摘要
Abstract
Background and Aims:Abdominal aortic aneurysm(AAA)is a life-threatening vascular disease closely associated with chronic inflammation and insulin resistance(IR).The C-reactive protein-triglyceride-glucose index(CTI),a novel composite biomarker integrating inflammatory and metabolic status,has shown prognostic value in cardiovascular diseases.However,its association with AAA risk remains unclear.This study aimed to investigate the relationship between CTI and incident AAA using data from the UK Biobank. Methods:A total of 315003 participants free of aneurysmal disease at baseline with available CTI data were included from the UK Biobank cohort.Incident AAA was defined as the primary outcome.Kaplan-Meier analysis was used to estimate the cumulative incidence of AAA across CTI levels,while multivariable regression models and restricted cubic spline(RCS)analysis were employed to evaluate the association between CTI and incident AAA risk and to assess the dose-response relationship.Subgroup and sensitivity analyses were conducted to assess the robustness of the findings. Results:During a median follow-up of 16.37 years,1343 participants developed AAA.Kaplan-Meier curves demonstrated a progressive increase in cumulative AAA incidence across CTI quartiles.In the fully adjusted model,each standard deviation increase in CTI was associated with a 39％higher risk of AAA(HR=1.39,95％CI=1.30-1.48).Compared with the lowest CTI quartile,participants in the highest quartile had a significantly elevated risk of AAA(HR=2.15,95％CI=1.73-2.66;Ptrend<0.001).RCS analysis revealed a significant nonlinear association between CTI and AAA risk(Pnon-linear=0.008).The association was more pronounced among current or former smokers,participants with HbA1c<48 mmol/mol,and those without hypertension,diabetes,coronary heart disease,or lipid-lowering medication use(all Pinteraction<0.05).Sensitivity analyses yielded consistent results. Conclusion:Elevated CTI was independently associated with an increased risk of incident AAA in a dose-dependent manner.CTI may serve as a readily available biomarker for early risk identification and risk stratification of AAA.关键词
主动脉瘤,腹/胰岛素抵抗/炎症/英国生物样本库Key words
Aortic Aneurysm,Abdominal/Insulin Resistance/Inflammation/UK Biobank分类
医药卫生引用本文复制引用
朱炫萌,谢伟,马天琪..基于UK Biobank的C-反应蛋白-甘油三酯-葡萄糖指数与腹主动脉瘤发病风险的前瞻性队列研究[J].中国普通外科杂志,2026,35(6):1161-1172,12.基金项目
国家自然科学基金资助项目(82401853). （82401853）
