中国比较医学杂志2026，Vol.36Issue(14)：83-91,9.DOI:10.3969/j.issn.1671-7856.2026.14.008
DHA和EPA在脂肪组织中缓解胰岛素抵抗的作用机制研究进展
Research progress on the mechanism of DHA and EPA in alleviating insulin resistance in adipose tissue
摘要
Abstract
Insulin resistance contributes substantially to the pathogenesis of metabolic diseases including obesity,and impaired adipose tissue function is pivotal for the onset of insulin resistance.In recent years,docosahexaenoic acid(DHA)and eicosapentaenoic acid(EPA),the main components of n-3 polyunsaturated fatty acids,have received extensive attention for their effects in alleviating insulin resistance.Numerous studies have shown that DHA and EPA can regulate adipose tissue.This article provides a comprehensive review of the mechanisms by which DHA and EPA alleviate insulin resistance in adipose tissue,focusing on anti-inflammatory effects,lipid metabolism regulation,diabetic pathways,and gut microbiota interactions.The findings offer theoretical foundations for further investigation into the molecular mechanisms involved in insulin resistance mitigation by these compounds,establishing a theoretical basis for developing drugs targeting metabolic diseases using n-3 polyunsaturated fatty acids.关键词
DHA/EPA/脂肪组织/胰岛素抵抗Key words
DHA/EPA/adipose tissue/insulin resistance分类
医药卫生引用本文复制引用
雷慧敏,杨铮,李骄洋,杨慧娣..DHA和EPA在脂肪组织中缓解胰岛素抵抗的作用机制研究进展[J].中国比较医学杂志,2026,36(14):83-91,9.基金项目
国家自然科学基金(32160247) （32160247）
内蒙古自然基金杰出青年项目(2024JQ14) （2024JQ14）
内蒙古医科大学重点项目(YKD2023ZD007) （YKD2023ZD007）
内蒙古医科大学治学人才项目(ZY20241301) （ZY20241301）
内蒙古医科大学创客培育项目(101322025050). （101322025050）
