中国比较医学杂志2026，Vol.36Issue(14)：92-101,10.DOI:10.3969/j.issn.1671-7856.2026.14.009
Sirt1/PGC-1α信号通路在睡眠障碍发病机制中的研究进展
Research progress of Sirt1/PGC-1α signaling pathway in the pathogenesis of sleep disorders
摘要
Abstract
Sleep disorders have emerged as a significant global public health issue,with their prevalence increasing annually.The underlying mechanisms remain complex and incompletely understood,involving multiple pathways such as oxidative stress,inflammatory responses,neurotransmitter imbalances,and neuroendocrine dysregulation.Sirt1/PGC-1α signaling plays a pivotal role in cellular metabolism,oxidative stress regulation,and mitochondrial function,and is implicated in sleep disorder pathogenesis.As a class Ⅲ histone deacetylase,Sirt1 activates antioxidant enzymes and suppresses the activity of inflammation-related transcription factors through deacetylation;acting as a transcriptional coactivator,PGC-1α regulates mitochondrial biogenesis and enhances mitochondrial antioxidant capacity.Their interaction jointly regulates oxidative stress,inflammatory responses,mitochondrial function,and neurotransmitter activity,improving pathological sleep disorder manifestations.Although research on the Sirt1/PGC-1α pathway has made progress,the specific mechanisms in different brain regions and cell types involved require further investigation.Optimizing drug development targeting this pathway is essential to provide stronger evidence for the precision treatment of sleep disorders.关键词
Sirt1/PGC-1α信号通路/睡眠障碍/氧化应激/炎症反应/线粒体功能Key words
Sirt1/PGC-1α signaling pathway/sleep disorders/oxidative stress/inflammatory response/mitochondrial function分类
医药卫生引用本文复制引用
李强,孙毅红,霍娇娇,杨占君,贾建新..Sirt1/PGC-1α信号通路在睡眠障碍发病机制中的研究进展[J].中国比较医学杂志,2026,36(14):92-101,10.基金项目
国家自然科学基金(82360264) （82360264）
内蒙古自治区自然科学基金(2024MS08051) （2024MS08051）
内蒙古自治区高等学校创新团队发展计划(NMGIRT2328). （NMGIRT2328）
