中国实用妇科与产科杂志2026，Vol.42Issue(7)：684-688,5.DOI:10.19538/j.fk2026070104
阴道鳞状上皮内病变的阴道镜诊断特点与临床管理
Colposcopic diagnostic features and clinical management of vaginal squamous intraepithelial lesion
摘要
Abstract
Vaginal squamous intraepithelial lesion,also known as vaginal intraepithelial neoplasia(VaIN),is a precursor lesion of vaginal cancer closely associated with persistent infection by high-risk human papillomavirus(HR-HPV).It has long been underrecognized in clinical practice due to its low incidence.In recent years,with the popularization and standardized application of colposcopy,the detection rate of VaIN has increased significantly.VaIN frequently coexists with cervical squamous intraepithelial lesion and has gradually become a key clinical concern as a major cause of recurrence or residual disease during follow-up after cervical lesion treatment.However,due to the unique anatomical structure of the vagina,VaIN presents diagnostic challenges such as occult lesions,multifocal distribution,and difficult exposure,resulting in a high rate of clinical missed diagnoses and hindering early intervention.This article systematically reviews the epidemiological characteristics of VaIN,its association with cervical lesions and post-treatment follow-up,colposcopic features and identification difficulties,biopsy strategies and risk control of missed diagnoses,as well as clinical management and follow-up principles for different grades of lesions.Based on the latest clinical research and consensus,it provides a reference for clinicians to standardize the diagnosis and management of VaIN.关键词
阴道鳞状上皮内病变/阴道镜检查/癌前病变/诊断/管理Key words
vaginal squamous intraepithelial lesion/colpos-copy/precancerous lesion/diagnosis/management分类
医药卫生引用本文复制引用
张璐,隋龙,陈飞,丛青..阴道鳞状上皮内病变的阴道镜诊断特点与临床管理[J].中国实用妇科与产科杂志,2026,42(7):684-688,5.基金项目
国家重点研发计划(2025YFC2708403) （2025YFC2708403）
国家自然科学基金面上项目(82573189) （82573189）
上海市卫生健康委员会智慧医疗项目(2025ZHYL006) （2025ZHYL006）
上海市卫生健康委员会医学新技术研究与转化种子项目(2025ZZ2007) National Key Research and Development Program(2025YFC2708403) （2025ZZ2007）
National Natural Science Foundation of China General Project(82573189) （82573189）
Shang-hai Municipal Health Commission's Digital Health Project(2025ZHYL006) （2025ZHYL006）
Shanghai Municipal Health Commis-sion's Medical New Technology Research and Translation Seed Project(2025ZZ2007) （2025ZZ2007）
