中国药理学通报2026，Vol.42Issue(8)：1401-1406,6.DOI:10.12360/CPB202510076
卒中后NETs介导免疫血栓的形成机制及神经血管损伤的研究进展
Research progress on mechanism of NETs-mediated immunothrombosis and neurovascular injury after stroke
摘要
Abstract
Immunothrombosis is an important pathological prod-uct that leads to microcirculation disturbance and aggravation of inflammatory response after stroke.This article focuses on neu-trophil extracellular traps(NETs),the core skeleton of immune thrombosis,and expounds the formation signals of NETs after stroke,including reactive oxygen species(ROS)storm,damaging-related molecular patterns release,and increased in-flammatory factors,and explores the key mechanism of its for-mation,such as peptidyl-arginine deiminase 4(PAD4)-medi-ated histone citrullination,ROS signaling pathway,granzyme,and analyzed the different types of NETosis.Furthermore,NETs directly damage the blood-brain barrier and glial cells,amplify the inflammatory response,and aggravate the damage of the neurovascular unit,thereby promoting each other to form a vicious circle.On this basis,we summarize the preclinical treatment strategies of NETs,providing new targets and theoreti-cal basis for the treatment of stroke.关键词
免疫血栓/NETs/中性粒细胞/脑卒中/血小板/炎症Key words
immunothrombosis/NETs/neutrophils/stroke/platelets/inflammation分类
医药卫生引用本文复制引用
屈山河,阮元,张天怡,楚世峰,陈乃宏..卒中后NETs介导免疫血栓的形成机制及神经血管损伤的研究进展[J].中国药理学通报,2026,42(8):1401-1406,6.基金项目
国家自然科学基金资助项目(No U2202214) （No U2202214）
