中国药理学通报2026，Vol.42Issue(8)：1407-1412,6.DOI:10.12360/CPB202512044
抗乌头类生物碱所致快速性心律失常的作用机制研究进展
Research progress on mechanisms of traditional Chinese medicine monomers against aconitum alkaloid-induced tachyarrhythmias
摘要
Abstract
Aconitum species are commonly used in traditional Chinese medicine(TCM)clinical practice.Their main active and toxic components,diester diterpenoid alkaloids(DDAs),can induce tachyarrhythmias(TA),which may become life-threatening in severe cases.In recent years,the frequent occur-rence of poisoning incidents caused by improper dosage,formu-lation,or processing has emerged as a major public health con-cern.Currently,targeted therapeutic agents for DDAs induced TA are still lacking in clinical practice,and conventional symp-tomatic treatments often lead to significant adverse effects.Therefore,there is an urgent need to explore safe and effective novel adjuvant therapeutic strategies.TCM offers extensive ex-perience in the prevention and treatment of aconite poisoning.On the one hand,various herbal monomers can exert synergistic therapeutic effects through multi-target mechanisms within dis-ease networks;on the other hand,processing methods can structurally modify DDAs to achieve targeted detoxification.This article systematically reviews recent advances in the mechanisms by which herbal monomers counteract DDAs in-duced TA,aiming to provide a theoretical basis for the develop-ment and clinical translation of novel detoxification strategies.关键词
中药单体/乌头类药材/双酯型二萜类生物碱/快速性心律失常/离子通道/电生理紊乱Key words
traditional Chinese medicine monomers/aconitum species/diester diterpenoid alkaloids/tachyarrhythmia/ion channels/electrophysiological disturbances分类
医药卫生引用本文复制引用
王思昀,许欣宜,张译方,王元翀,缪长宏,肖璐,周奕珩..抗乌头类生物碱所致快速性心律失常的作用机制研究进展[J].中国药理学通报,2026,42(8):1407-1412,6.基金项目
国家自然科学基金资助项目(No 82405123) （No 82405123）
河北省中医药管理局科研项目(No T2025106) （No T2025106）
睿E急诊医学研究基金(No PUMF01010010-2024-07) （No PUMF01010010-2024-07）
急症部学科发展基金(No XKJJ201715) （No XKJJ201715）
天津市卫健委中医中西医结合课题(No 2023070) （No 2023070）
