中国药理学通报2026，Vol.42Issue(8)：1418-1423,6.DOI:10.12360/CPB202602004
特异性突触吞噬:肠生态失衡与睡眠障碍并发抑郁症的分子连接机制
Specific synaptic phagocytosis:molecular linking mechanism between gut dysbiosis and depression complicating sleep disorders
摘要
Abstract
Sleep disorders and depression are closely related in onset,but their shared neurobiological underpinnings and thera-peutic targets remain unclear,hindering effective clinical inter-ventions.The"gut-brain axis"theory proposes gut microbiota as a crucial peripheral regulator,influencing central nervous system changes such as neurotransmitter levels and synaptic plasticity impairment.Gut dysbiosis compromises the intestinal barrier,triggering systemic inflammation and blood-brain bar-rier damage,leading to metabolic and epigenetic reprogram-ming of brain microglia.This results in specific synaptic prun-ing of emotion-and sleep-related neural circuits,ultimately causing comorbidity.Resulting stress behaviors further exacer-bate gut dysfunction via hypothalamic-pituitary-adrenal(HPA)axis activation,creating a vicious cycle.Delving into the"microbiota-immune-epigenetic-neural circuit"network pro-vides an integrative framework for understanding comorbidity.Incorporating the traditional Chinese medicine perspective"a restless stomach leads to restless sleep",this study elucidates correspondences between TCM patterns and modern gut-brain axis mechanisms,demonstrating the potential for complemen-tary and integrative insights.关键词
睡眠障碍/抑郁症/肠-脑轴/小胶质细胞/特异性突触吞噬/神经环路失调Key words
sleep disorders/depression/gut-brain axis/mi-croglia/specific synaptic phagocytosis/neural circuit dysregu-lation分类
医药卫生引用本文复制引用
余敏婕,邹蔓姝,杨蕙,韩远山,雷昌,赵洪庆,贺海霞,王宇红..特异性突触吞噬:肠生态失衡与睡眠障碍并发抑郁症的分子连接机制[J].中国药理学通报,2026,42(8):1418-1423,6.基金项目
国家自然科学基金资助项目(No 82575029,82505530) （No 82575029,82505530）
湖南省重大基础研究项目(No 2025JC0006) （No 2025JC0006）
校级科研基金项目"揭榜挂帅"专项(No Z2023JBGS03) （No Z2023JBGS03）
2025年度"院士工作站"指导项目(No 25YS003) （No 25YS003）
湖南省科药联合基金(No 2024JJ8192,2025JJ80123) （No 2024JJ8192,2025JJ80123）
