中国药理学通报2026，Vol.42Issue(8)：1424-1429,6.DOI:10.12360/CPB202601126
钩藤生物碱治疗神经系统疾病的研究进展
Research progress on uncaria alkaloids in treatment of neurological diseases
摘要
Abstract
Nervous system diseases have complex pathogen-esis,and the existing therapeutic drugs have not yet met clini-cal needs.Uncaria rhynchophylla is sweet in taste and cool in nature,with the effects of calming endogenous wind to stop con-vulsions,clearing heat and pacifying the liver.Modern pharma-cological studies have shown that Uncaria rhynchophylla con-tains various active ingredients such as rhynchophylline and iso-rhynchophylline,which can exert neuroprotective effects through multiple targets and pathways.The specific mecha-nisms include regulating calcium ion homeostasis,alleviating oxidative stress,inhibiting neuroinflammation,regulating neu-rotransmitters,protecting the blood-brain barrier,and inhibit-ing neuronal apoptosis.Uncaria alkaloids have obvious advan-tages and potential in the treatment of various nervous system diseases.This article systematically reviews the mechanisms underlying the preventive and therapeutic effects of uncaria al-kaloids on different neurological diseases,aiming to provide a theoretical basis and research directions for the application of uncaria in neurological disorders and the development of related innovative drugs.关键词
钩藤生物碱/神经系统疾病/药理机制/研究进展/神经保护/钩藤碱Key words
uncaria alkaloids/nervous system diseases/phar-macological mechanisms/research progress/neuroprotection/rhynchophylline分类
医药卫生引用本文复制引用
贺晨菲,冉春龙,白琛,潘小龙,刘向哲..钩藤生物碱治疗神经系统疾病的研究进展[J].中国药理学通报,2026,42(8):1424-1429,6.基金项目
国家重点研发项目(No 2022YFC3501103) （No 2022YFC3501103）
河南省科学技术厅科技攻关项目(No 242102311277) （No 242102311277）
河南省中医药科学研究专项课题(No 2023ZXZX1077) （No 2023ZXZX1077）
河南省中医药传承与创新人才工程(仲景工程)中医药学科领军人才项目[No 豫卫中医函(2021)8号] （仲景工程）
