中华中医药杂志2026，Vol.41Issue(7)：1865-1869,5.
基于"因加而发"探析特发性肺纤维化急性加重病机与防治
Exploration on the pathogenesis and prevention and treatment of acute exacerbation of idiopathic pulmonary fibrosis based on the theory of'disease with latent pathogen induced by a new pathogen'
摘要
Abstract
Acute exacerbation of idiopathic pulmonary fibrosis(AE-IPF)is a major cause of mortality among IPF patients.The theory of'disease with latent pathogen induced by a new pathogen'originates from the Huangdi Neijing,emphasizes that the disease exacerbation occurs when latent pathogenic factors within the body are triggered by new pathogenic influences.Building upon the theory of'disease with latent pathogen induced by a new pathogen',this article explores the pathogenesis and prevention and treatment of AE-IPF.The'latent pathogen'refers to the pre-existing condition of'lung deficiency with stasis in the collaterals' formed during the stable phase of IPF;the'new pathogen'refers to the new pathogenic factors that stir the latent pathogens.Ultimately,the combination of these old and new pathogenic factors creates a pattern of'lung heat with stasis in the collaterals',thereby triggering AE-IPF.In terms of treatment,prior to the onset of the disease,one should'strengthen the root and eliminate the cause,whilst carefully avoiding external pathogenic factors';during the acute exacerbation phase,one should'treat the manifestation and eliminate the addition,providing emergency care and preventing deterioration';and during the recovery phase,one should'combine clearing and nourishing,supporting the vital qi and ensuring a favorable outcome'.This provides new insights and a theoretical basis for the prevention and treatment of AE-IPF.关键词
特发性肺纤维化/急性加重/病因病机/因加而发/防治Key words
Idiopathic pulmonary fibrosis(IPF)/Acute exacerbation/Etiology and pathogensis/Disease with latent pathogen induced by a new pathogen/Prevention and treatment引用本文复制引用
于淼,吕晓东,庞立健,王琳琳,陈芷怡,王诗怡,王梓,栾海军,何鑫垚,孙一博,王浩同..基于"因加而发"探析特发性肺纤维化急性加重病机与防治[J].中华中医药杂志,2026,41(7):1865-1869,5.基金项目
国家科技重大专项(No.2024ZD0522904),2024年辽宁省"兴辽英才计划"医学名家项目(No.XLYC2412001),辽宁省"兴辽英才计划"高水平创新团队项目(No.XLYC1808011),辽宁省教育厅基本科研项目(No.LJ222410162054),2023年度沈阳市科学技术计划项目(No.23-504-3-09),辽宁中医药大学青年科技创新团队项目(No.2024-JYTCB-078) （No.2024ZD0522904）
