中华中医药杂志2026，Vol.41Issue(7)：1870-1873,4.
基于肠道区域免疫特性探讨"脾为之使"的隐喻与明证
Discussion on the metaphor and evidence of'spleen serving as the messenger'based on the intestinal regional immunity characteristics
摘要
Abstract
Based on metaphorical cognition,this paper aims to build a bridge between modern medicine and traditional Chinese medicine theories.As the'messenger'of the five zang-organs,the spleen has the functions of transport,dispersing sperm,rotating the pivot and guarding the body.With the development of gut microbiota-immunity research,the regulatory mechanism of the immune system in the intestinal region is in line with the'spleen serving as the messenger'.Therefore,the'spleen serving as the messenger'is taken as the'source domain'and the characteristics of the intestinal regional immunity is the'target domain',and the theoretical connotation of'spleen serving as the messenger'from the perspective of metaphorical cognition,is revealed by analyzing the immune interaction of the gut microbiota,which provides modern scientific evidence for the theory of'spleen serving as the messenger'and provides a basis for the modern interpretation of the spleen and stomach theory of traditional Chinese medicine.关键词
脾为之使/隐喻/肠道区域免疫/肠道菌群/固有免疫/适应性免疫Key words
Spleen serving as the messenger/Metaphor/Intestinal regional immunity/Gut microbiota/Innate immunity/Adaptive immunity引用本文复制引用
李学盈,吴诗昀,李梦君,吴亚兰,骆欢欢..基于肠道区域免疫特性探讨"脾为之使"的隐喻与明证[J].中华中医药杂志,2026,41(7):1870-1873,4.基金项目
国家自然科学基金项目(No.82174244,No.81973720),中医药广东省实验室培植项目(No.HQL2024PZ035) （No.82174244,No.81973720）
