中国中药杂志2026，Vol.51Issue(11)：3105-3116,12.DOI:10.19540/j.cnki.cjcmm.20260309.501
呼吸系统耐药菌感染的中医认识与治疗策略
TCM understanding and therapeutic strategies for respiratory drug-resistant bacterial infections
摘要
Abstract
Currently,respiratory drug-resistant bacterial infections are a major global public health challenge due to their protracted course of disease and suboptimal treatment outcomes.In the face of slow progress in the development of new antibiotics,TCM offers novel perspectives for preventing and treating such infections by leveraging its unique advantages in holistic regulation and syndrome differentiation.This paper,for the first time,systematically constructed a TCM composite pathogenesis model centered on the core concept of bacteria-toxin-stasis-deficiency.It elucidated the dynamic evolution pattern characterized by deficiency in nature and excess in superficiality and proposed a stage-specific and syndrome-specific diagnostic and therapeutic framework,along with a prevention and treatment strategy of advancing intervention to intercept and reverse disease progression.From a TCM perspective,these infections can be categorized under conditions such as wind-warmth,lung abscess,cough,or latent pathogen.The key pathogenesis involves"internal deficiency of lung Qi leading to lingering pathogenic factors",resulting in the mutual binding of phlegm,stasis,and toxins in the lungs.Based on the dynamic interplay between healthy Qi and pathogenic factors,the clinical presentation can be divided into two phases:pathogen excess with healthy Qi impairment and healthy Qi deficiency with lingering pathogen.These phases encompass core syndrome types including healthy Qi deficiency with lingering pathogen,latent pathogen in pleurodiaphragmatic interspace,phlegm-stasis-toxin binding,and dual deficiency of Qi and Yin.Therapeutically,modified classical formulas such as Maxing Shigan Decoction,Zhuye Shigao Decoction,Dayuanyin,Qianjin Weijing Decoction,and Shashen Maidong Decoction are employed to embody the principle of reinforcing healthy Qi and eliminating pathogen.Clinical practice demonstrates that adhering to an integrated traditional Chinese and western medicine model guided by the principles of integrating pathogenesis with pathology and medicinal properties with pharmacology can effectively improve patient prognosis,reduce recurrence rates,and enhance quality of life.This approach provides a new paradigm of integrated traditional Chinese and western medicine for addressing the global crisis of antimicrobial resistance.关键词
呼吸系统耐药菌感染/中医药/伏邪/痰瘀毒结/扶正祛邪/菌-毒-瘀-虚模型Key words
respiratory drug-resistant bacterial infection/TCM/latent pathogen/phlegm-stasis-toxin binding/reinforcing healthy Qi and eliminating pathogen/bacteria-toxin-stasis-deficiency model引用本文复制引用
刘永辉,林韩东,张丽明,黄语嫣,林江,邓亚胜,韦俊全,臧明月,张荣昶,陈秋,兰太进,庞业展..呼吸系统耐药菌感染的中医认识与治疗策略[J].中国中药杂志,2026,51(11):3105-3116,12.基金项目
四大慢病重大专项(2023ZD0509400) （2023ZD0509400）
国家自然科学基金项目(82060825) （82060825）
全国高校黄大年式教师团队——中西医基础课程教师团队项目(教育部教师函[2022]2号) （教育部教师函[2022]2号）
广西名中医林江传承工作室项目(桂中医药科教发[2021]6号) （桂中医药科教发[2021]6号）
中医学广西一流学科项目(桂教科研[2022]1号) （桂教科研[2022]1号）
广西中医药创新团队项目(GZKJ2302) （GZKJ2302）
