中国中药杂志2026，Vol.51Issue(12)：3317-3324,8.DOI:10.19540/j.cnki.cjcmm.20260316.301
生物膜仿生制剂治疗心肌缺血性损伤的研究进展
Research progress of biomimetic membrane preparation for myocardial ischemic injury treatment
摘要
Abstract
Myocardial ischemic injury threatens human health.While monomers or compound formulas of TCM can ameliorate such injury through multi-target and multi-pathway mechanisms,their clinical efficacy is hampered by poor targeting and low bioavailability.In recent years,biomimetic membrane preparations,primarily biomimetic cell membrane preparations and exosomes,have emerged as a novel therapeutic strategy for myocardial ischemic injury.Owing to their natural bioactivity,easy engineerability,and other characteristics,they enable the targeted delivery of TCM components to ischemic lesions and facilitate their transport across biological barriers.This review focused on the core pathological mechanisms of myocardial ischemic injury,elaborated on the types and unique functions of biomimetic cell membrane preparations and exosomes,and provided a critical analysis of the design strategies and action mechanisms of such biomimetic cell membrane preparations.Furthermore,it discussed the adaptability of different administration routes and highlighted the potential and the existing challenges of natural biomimetic membrane preparations.The aim of this study is to offer insights for the design,research,and development of biomimetic preparations for myocardial ischemic injury.关键词
心肌缺血性损伤/靶向递药系统/细胞膜仿生制剂/外泌体/给药途径Key words
myocardial ischemia injury/targeted drug delivery system/biomimetic cell membrane preparation/exosome/administration route引用本文复制引用
刘雪梅,刘雨菲,杨千年,李留洋,高小力,王金铃..生物膜仿生制剂治疗心肌缺血性损伤的研究进展[J].中国中药杂志,2026,51(12):3317-3324,8.基金项目
国家自然科学基金项目(82173987) （82173987）
国家中医药管理局高水平重点学科-中药药剂学项目(zyyzdxk-2023272) （zyyzdxk-2023272）
