中国中药杂志2026，Vol.51Issue(12)：3325-3339,15.DOI:10.19540/j.cnki.cjcmm.20260305.706
甘草酸抗肿瘤的药理活性及作用机制研究进展
Research progress on anti-tumor pharmacological activities and mechanisms of glycyrrhizic acid
摘要
Abstract
The incidence and mortality of malignant tumors remain persistently high,while current clinical chemotherapeutic agents are often limited by significant drug resistance and adverse reactions.Consequently,small-molecule compounds derived from traditional Chinese medicine(TCM)have emerged as a focus in anti-tumor research owing to their advantages of multi-targeting action and low toxicity.As the core active component of Glycyrrhiza uralensis,glycyrrhizic acid(GA)is an oleanane-type pentacyclic triterpenoid saponin,constituting 5%-11%of the total content of G.uralensis.Its anti-tumor activity has been validated across various tumor systems,with mechanisms of action encompassing key processes such as cell cycle arrest,induction of tumor cell apoptosis,inhibition of tumor angiogenesis,blockage of invasion and metastasis,regulation of the tumor immune microenvironment(TIME),and alleviation of chronic inflammation.In terms of its therapeutic value,the combination of glycyrrhizic acid with other agents,such as tanshinone ⅡA(Chinese medicine)or cisplatin(conventional chemotherapy)can achieve enhanced efficacy,reduced toxicity,targeted delivery,and reversal of drug resistance.This positions GA as possessing dual values,functioning both as a therapeutic agent and as a drug delivery carrier.This review systematically summarized the anti-tumor pharmacological activities,mechanisms,combined medication potential,and safety profiles of GA.It elaborated on the network mechanism of core regulatory hubs,analyzed the limitations of current research,and proposed targeted strategies for clinical translation.This work aims to provide a reference for the transition of GA from fundamental research to clinical application,while also offering a paradigm for the development of anti-tumor small-molecule compounds from TCM.关键词
甘草酸/恶性肿瘤/作用机制/联合用药/安全性/临床转化Key words
glycyrrhizic acid/malignant tumor/mechanism/combined medication/safety/clinical transformation引用本文复制引用
雷一鸣,崔烁蓥,王琳琳,张海波,付俊敏,仝如意,张梦露..甘草酸抗肿瘤的药理活性及作用机制研究进展[J].中国中药杂志,2026,51(12):3325-3339,15.基金项目
河南省科技攻关项目(232102311191) （232102311191）
河南省科技研发计划联合基金(优势学科培育类)项目(242301420111) （优势学科培育类）
河南省自然科学基金项目(242300421520) （242300421520）
河南省大学生创新创业训练计划项目(S202510471033) （S202510471033）
