中国中药杂志2026，Vol.51Issue(12)：3352-3363,12.DOI:10.19540/j.cnki.cjcmm.20260209.203
常见多孔菌科中药多糖分离纯化、结构表征和生物活性研究进展
Research progress in separation,purification,structural characterization,and bioactivities of polysaccharides from common traditional Chinese medicine derived from Polyporaceae
摘要
Abstract
Polyporaceae fungi are recognized as significant medicinal resources and are documented in the Chinese Pharmacopoeia(2025)Volume Ⅰ,with representatives including Ganoderma,Poria,Polyporus,and Coriolus.Polyporaceae fungi polysaccharides(PFPs)are regarded as one of the principal bioactive constituents,exhibiting diverse biological activities.The polysaccharide yield is considerably influenced by the extraction methods employed,with solvent extraction,ultrasound-assisted,microwave-assisted,and enzyme-assisted extraction being widely used.To obtain homogeneous polysaccharides,purification typically involves a combination of techniques such as deproteinization,decolorization,ultrafiltration,and various forms of chromatography.Structural analyses indicate that PFPs are primarily composed of neutral polysaccharides and acidic polysaccharides,which display considerable complexity and diversity in monosaccharide composition,molecular weight,and glycosidic linkage configurations.Pharmacological studies have revealed that PFPs possess multiple biological activities,including antitumor,immunomodulatory,antioxidant,gut microbiota-regulating,neuroprotective,and hepatoprotective effects.This review comprehensively summarizes recent advances in the extraction,purification,structural characterization,and biological activities of PFPs,aiming to provide a valuable reference for their further development and comprehensive utilization.关键词
多孔菌科/多糖/提取分离/结构表征/生物活性Key words
Polyporaceae/polysaccharides/extraction and purification/structural characterization/biological activities引用本文复制引用
张德赟,朱阳东,李梦茹,张明世,尹秋燕,于斋卓,闫滨..常见多孔菌科中药多糖分离纯化、结构表征和生物活性研究进展[J].中国中药杂志,2026,51(12):3352-3363,12.基金项目
国家自然科学基金项目(82374311) （82374311）
