中国中药杂志2026，Vol.51Issue(12)：3364-3386,23.DOI:10.19540/j.cnki.cjcmm.20260209.201
伞形科药用植物中酞类成分及其药理活性研究进展
Research progress in phthalides in medicinal species of Apiaceae and their pharmacological activities
摘要
Abstract
Plants of Apiaceae represent an important group of Chinese medicinal herbs.Phthalides,as the key bioactive constituents in these plants,exhibit a wide range of pharmacological effects and possess significant research value.This article systematically reviews recent advances in the chemical structures and pharmacological activities of phthalides derived from medicinal species of Apiaceae.To date,295 phthalides have been isolated and identified from these plants,and they can be categorized into four structural types:monomeric phthalides,dimeric phthalides,trimeric phthalides,and phthalide heteropolymers.This article comprehensively discussed the structural diversity of dimeric and trimeric phthalides,including various[2+2]and[4+2]cycloaddition coupling modes and their proposed biosynthetic pathways.It is noted that enantiomerism is prevalent among these compounds.Specifically,most dimeric phthalides,all trimeric phthalides,and some phthalide heteropolymers and monomeric phthalides have been obtained as racemates.Pharmacological studies have revealed that these compounds exhibit notable neuroprotective,antitumor,anti-inflammatory,and cerebrovascular disease-preventing activities.Among them,butylphthalide has been successfully applied in clinical practice.By providing a comprehensive overview of phthalides in medicinal species of Apiaceae and their pharmacological properties,this review aims to support further development and utilization of these plants and facilitate innovative drug research.关键词
伞形科/二聚酞类/三聚酞类/酞杂聚体/对映体/抗肿瘤/抗氧化/抗炎Key words
Apiaceae/dimeric phthalides/trimeric phthalides/phthalide heteropolymers/enantiomers/anti-tumor/anti-oxidant/anti-inflammation引用本文复制引用
夏召,张海新,邵晶..伞形科药用植物中酞类成分及其药理活性研究进展[J].中国中药杂志,2026,51(12):3364-3386,23.基金项目
2025 年甘肃省科技计划联合科研基金项目(25JRRA1175) （25JRRA1175）
2025 年甘肃省中医药科研课题重点课题(GZKZ-2025-55) （GZKZ-2025-55）
2024 年兰州市第三批科技计划项目科技支撑专项(2024-3-35) （2024-3-35）
2024 年国家药监局中药材及饮片质量控制重点实验室科研项目(2024GSMPA-KL14) （2024GSMPA-KL14）
