中国中药杂志2026，Vol.51Issue(13)：3631-3636,6.DOI:10.19540/j.cnki.cjcmm.20260403.361
整合"传统功效-物质基础-作用靶点"的中药药效物质敲出/敲入辨识新范式
New paradigm for identifying pharmacodynamic substances of TCM through knock-out/knock-in technique by integrating traditional efficacy,material basis,and action targets
摘要
Abstract
TCM is a treasure of Chinese civilization and a potential key to solving modern medical challenges.Research on the pharmacodynamic material basis,action targets,and mechanisms based on the traditional efficacy of TCM has become a consensus.Clarifying the pharmacodynamic material basis of TCM is not only a fundamental issue in TCM research but also a critical step in deciphering the complex TCM systems.However,the complexity of TCM systems poses significant challenges to the research of their pharmacodynamic material basis,leaving the pharmacodynamic material basis of treating diseases in most TCM largely unclear,which greatly limits people's scientific understanding of TCM in treating diseases.Currently,the research on the pharmacodynamic material basis of TCM has formed an interdisciplinary methodological system.Various methods have shown unique advantages,but they all have the common problem of being unable to balance the holistic view of TCM and research precision.The knock-out/knock-in technique can precisely disassemble and controllably integrate the complex TCM system and is a key technique to solve the challenges in the research of TCM material basis.Based on this,this paper proposed a new paradigm for identifying the material basis based on the knock-out/knock-in technique.This paradigm integrates the intrinsic connection among traditional efficacy,material basis,and action targets,aiming to provide new ideas for the research on the material basis of TCM and methodological support for the TCM modernization.关键词
中药物质基础/敲出/敲入/新范式/传统功效/作用靶点Key words
TCM material basis/knock-out/knock-in/new paradigm/traditional efficacy/action target引用本文复制引用
唐阳,肖炜婷,刘薇,夏明君,刘畅,王雄龙,李顺祥,欧阳文..整合"传统功效-物质基础-作用靶点"的中药药效物质敲出/敲入辨识新范式[J].中国中药杂志,2026,51(13):3631-3636,6.基金项目
湖南省自然科学基金高校联合基金项目(2025JJ90088) （2025JJ90088）
湖南省大学生创新创业训练计划项目(湘教通[2025]141号) （湘教通[2025]141号）
中央引导地方科技发展项目(2025ZYC011) （2025ZYC011）
湖南省教育厅科学研究重点项目(23A0303) （23A0303）
湖南中医药大学重点学科中药学科项目(校行发规字[2023]2号) （校行发规字[2023]2号）
