中国中药杂志2026，Vol.51Issue(13)：3637-3645,9.DOI:10.19540/j.cnki.cjcmm.20260416.363
逍遥散加减方治疗乳腺癌的研究进展
Research progress on treatment of breast cancer with modified Xiaoyao Powder
摘要
Abstract
Xiaoyao Powder,originally documented in the Taiping Huimin Heji Jufang(Beneficial Formulas from the Taiping Imperial Pharmacy),possesses the therapeutic actions of soothing the liver and nourishing the blood,as well as fortifying the spleen and dispelling dampness.It is regarded as one of the representative formulas within the harmonizing and releasing category.Subsequent generations have continuously modified this formula to accommodate evolving clinical demands.In recent years,this formula has been extensively applied in the prevention and treatment of breast cancer.This article retrieves and collates relevant literature from the past two decades to summarize the application of modified Xiaoyao Powder in breast cancer across three domains:formula and syndrome analysis,clinical research,and mechanism investigation.Formula and syndrome analysis reveals that this formula is particularly adept at addressing disorders arising from emotional disturbances and dysregulation of Qi and blood,aligning closely with the pathogenesis of liver depression and Qi stagnation as well as Qi and blood deficiency observed in breast cancer patients.In terms of clinical research,this formula can ameliorate breast cancer-associated complications such as climacteric-like syndrome,anxiety,depression,insomnia,and fatigue.It serves as an adjunct to surgical intervention,radiotherapy,and chemotherapy to improve therapeutic efficacy,reduce recurrence and metastasis rate,and modulate immune function.Furthermore,it exerts a certain inhibitory effect on precancerous breast lesions.Mechanistically,this formula demonstrates capacities to inhibit breast cancer proliferation and metastasis,induce apoptosis,regulate the tumor microenvironment and macrophage function,bidirectionally modulate the endogenous antioxidant system,suppress the"brain-mammary neural connection",and reverse cellular drug resistance.Through the aforementioned three aspects,this article provides a comprehensive exposition of the current research status of modified Xiaoyao Powder in the treatment of breast cancer,summarizes existing limitations in both clinical and mechanistic investigations,and proposes corresponding improvements,with the aim of providing a foundation and conceptual framework for subsequent in-depth studies.关键词
逍遥散/乳腺癌/临床应用/作用机制/研究进展Key words
Xiaoyao Powder/breast cancer/clinical application/mechanism of action/research progress引用本文复制引用
董嘉楠,朱燃培,李欢,贺芳芳,郑玉玲..逍遥散加减方治疗乳腺癌的研究进展[J].中国中药杂志,2026,51(13):3637-3645,9.基金项目
全国名老中医药专家传承工作室建设项目(国中医药人教函[2022]75号) （国中医药人教函[2022]75号）
全国名中医传承工作室建设项目(国中医药人教函[2022]245号) （国中医药人教函[2022]245号）
中西医防治重大疾病河南省协同创新中心项目(教科技[2023]413号) （教科技[2023]413号）
河南省中医高水平专科培育项目(肿瘤科)(cz0317-10) （肿瘤科）
河南中医药大学2024年度研究生科研创新能力提升计划项目(2024KYCX009,2024KYCX013) （2024KYCX009,2024KYCX013）
